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Coat Colour Merle

Breed: ALL

Generic Phene Data

Breeds

Relevance Rating: Some evidence for test being meaningful in this breed

ALL

General

Disease Name
Coat Colour Merle
Mutation
NC_006592.3 (327618..292595)
Mutation 2
SINE oligo(dT) insertion
Test Type
Other Genetic Traits
Details
The merle gene (in the M locus) dilutes random sections of the coat to a lighter colour (usually grey in a black-pigmented dog), leaving patches of the original colour remaining. The patches can be any size and can be located anywhere. The edges of the patches may appear "torn" unlike the rounded spots of a Dalmatian. Merle affects only eumelanin, meaning that any black, liver, blue or isabella in the coat, eyes or nose will be merled, whether it's the whole of the body or in patches. Phaeomelanin (red) is not affected at all and will appear as normal. Merle is dominant, meaning all "normal" merles are heterozygous (Mm). A homozygous merle is actually a "double" merle (MM), which can result in serious health issues. Including deafness, blindness, sun sensitivity and skin cancer. For this reason two merles should never be bred together, as this will result in some double merle puppies. In many countries, these matings are banned from registration. As reported by Clark et al. (2006)(citing Sorsby and Davey (1954), "Dogs having Mm and MM genotypes typically have blue eyes and often exhibit a wide range of auditory and ophthalmologic abnormalities" As breeding merle dogs can be very challenging in avoiding producing merle x merle puppies, it is especially important to take breeding advice.
Details 2
The merle gene (in the M locus) dilutes random sections of the coat to a lighter colour (usually grey in a black-pigmented dog), leaving patches of the original colour remaining. The patches can be any size and can be located anywhere. The edges of the patches may appear "torn" unlike the rounded spots of a Dalmatian. Merle affects only eumelanin, meaning that any black, liver, blue or isabella in the coat, eyes or nose will be merled, whether it's the whole of the body or in patches. Phaeomelanin (red) is not affected at all and will appear as normal. Merle is dominant, meaning all "normal" merles are heterozygous (Mm). A homozygous merle is actually a "double" merle (MM), which can result in serious health issues. Including deafness, blindness, sun sensitivity and skin cancer. For this reason two merles should never be bred together, as this will result in some double merle puppies. As reported by Clark et al. (2006)(citing Sorsby and Davey (1954), "Dogs having Mm and MM genotypes typically have blue eyes and often exhibit a wide range of auditory and ophthalmologic abnormalities"
Published
Clark, LA., Wahl, JM., Rees, CA., Murphy, KE. : From The Cover: Retrotransposon insertion in SILV is responsible for merle patterning of the domestic dog. Proc Natl Acad Sci U S A 103:1376-81, 2006. Pubmed reference: 16407134. DOI: 10.1073/pnas.0506940103.

Breed Specific Data

Zoolyx

GTP
GTP Name
Zoolyx
Breed
ALL
Gene Name
PMEL
Mutation
NC_006592.3 (327618..292595); SINE oligo(dT) insertion

Progènes-ADN

GTP Name
Progenes ADN
Breed
ALL
Gene Name
PMEL
Mutation
NC_006592.3 (327618..292595); SINE oligo(dT) insertion

PharmaDNA

GTP
GTP Name
PharmaDNA
Breed
ALL
Gene Name
PMEL
Mutation
NC_006592.3 (327618..292595); SINE oligo(dT) insertion

Laboratorios Labocor S.L.

GTP Name
Laboratorios Labocor S.L.
Breed
ALL
Gene Name
PMEL
Mutation
NC_006592.3 (327618..292595); SINE oligo(dT) insertion

INNO

GTP
GTP Name
INNO
Breed
ALL
Gene Name
PMEL
Mutation
NC_006592.3 (327618..292595); SINE oligo(dT) insertion

CMSCH

GTP
GTP Name
CMSCH
Breed
ALL
Gene Name
PMEL
Mutation
NC_006592.3 (327618..292595); SINE oligo(dT) insertion

BioBank AS

GTP Name
BioBank AS
Breed
ALL
Gene Name
PMEL
Mutation
NC_006592.3 (327618..292595); SINE oligo(dT) insertion

Agrotis S.r.l.

GTP Name
Agrotis S.r.l.
Breed
ALL
Gene Name
PMEL
Mutation
NC_006592.3 (327618..292595); SINE oligo(dT) insertion

Certagen GmbH

GTP Name
Certagen GmbH
Breed
ALL
Gene Name
PMEL
Mutation
NC_006592.3 (327618..292595); SINE oligo(dT) insertion

GenSol Diagnostics

GTP Name
GenSol Diagnostics
Breed
ALL
Gene Name
PMEL
Mutation
SINE oligo(dT) insertion

Wisdom Health (formerly Mars Veterinary)

GTP Name
Wisdom Health (formerly Mars Veterinary)
Breed
ALL
Gene Name
PMEL
Mutation
NC_006592.3 (327618..292595)
GTP Breed
ALL

VHL Genetics

GTP Name
VHL Genetics
Breed
ALL
Gene Name
PMEL
Mutation
NC_006592.3 (327618..292595); SINE oligo(dT) insertion

Veterinary Genetics Laboratory

GTP Name
Veterinary Genetics Laboratory
Breed
ALL
Gene Name
PMEL
Mutation
NC_006592.3 (327618..292595)
GTP Breed
ALL

Paw Print Genetics

GTP Name
Paw Print Genetics
Breed
ALL
Gene Name
PMEL
Mutation
NC_006592.3 (327618..292595)

Laboklin Gmbh & Co. KG

GTP Name
Laboklin Gmbh & Co. KG
Breed
ALL
Gene Name
PMEL
Mutation
NC_006592.3 (327618..292595)

Genoscoper Laboratories Oy

GTP Name
Genoscoper Laboratories Oy
Breed
ALL
Gene Name
PMEL
Mutation
NC_006592.3 (327618..292595)
GTP Breed
ALL

Genomia s.r.o

GTP Name
Genomia s.r.o
Breed
ALL
Gene Name
SILV (PMEL17)
Mutation
SINE oligo(dT) insertion
GTP Breed
ALL

Antagene

GTP
GTP Name
Antagene
Breed
ALL
Gene Name
PMEL
Mutation
NC_006592.3 (327618..292595)
GTP Breed
ALL
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