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Curly Coat

Breed: ALL

Generic Phene Data

Breeds
ALL

General

Disease Name
Curly Coat
OMIA
245
Gene Name
KRT71
Mutation
c.451C>T
OMIM
608245
Test Type
Other Genetic Traits
Details
This influences the texture of the dog coat and hair formation. Inheritance (or "options" for coat type) is related to breed. The allele CC is dominant, and results in a curly coat. Only when the dog has two copies of the recessive allele is the coat is of a non-curly type. Some breeds are fixed (only ever curly-coated) for the dominant allele CC. Other breeds can have either curly or non-curly hair. Not to be confused with "curly coat/dry eye" which is a disease.
Published
Cadieu, E., Neff, M.W., Quignon, P., Walsh, K., Chase, K., Parker, H.G., Vonholdt, B.M., Rhue, A., Boyko, A., Byers, A., Wong, A., Mosher, D.S., Elkahloun, A.G., Spady, T.C., André, C., Lark, K.G., Cargill, M., Bustamante, C.D., Wayne, R.K., Ostrander, E.A. : Coat variation in the domestic dog is governed by variants in three genes. Science 326:150-3, 2009. Pubmed reference: 19713490. DOI: 10.1126/science.1177808.
Published 2
Parker, H.G., Harris, A., Dreger, D.L., Davis, B.W., Ostrander, E.A. : The bald and the beautiful: hairlessness in domestic dog breeds. Philos Trans R Soc Lond B Biol Sci 372:, 2017. Pubmed reference: 27994129. DOI: 10.1098/rstb.2015.0488.
Published 3
Harel, S., Christiano, A.M. : Keratin 71 mutations: from water dogs to woolly hair. J Invest Dermatol 132:2315-7, 2012. Pubmed reference: 22971920. DOI: 10.1038/jid.2012.291.
Body/System/Process
Coat Colour/Pattern/Type
Inheritance
A

Breed Specific Data

CAG GmbH Center for Animal Genetics

Link to GTP
Breed
ALL
OMIA
GTP Disease Name
Cu Locus (Curly Hair)
Gene Name
KRT71
Mutation
c.451C>T
Nature of test
mutation test

Genoscoper Laboratories Oy

Link to GTP
Breed
ALL
OMIA
GTP Disease Name
Cu Locus (Curly Hair)
Gene Name
KRT71
Mutation
c.451C>T
Nature of test
mutation test

Laboklin Gmbh & Co. KG

Link to GTP
Breed
ALL
OMIA
GTP Disease Name
Cu Locus (Curly Hair)
Gene Name
KRT71
Mutation
c.451C>T
Nature of test
mutation test

Paw Print Genetics

Link to GTP
Breed
ALL
OMIA
GTP Disease Name
Cu Locus (Curly Hair)
Gene Name
KRT71
Mutation
c.451C>T
Nature of test
mutation test

Veterinary Genetics Laboratory

Link to GTP
Breed
ALL
OMIA
GTP Disease Name
Cu Locus (Curly Hair)
Gene Name
KRT71
Mutation
c.451C>T
Nature of test
mutation test
GTP- or Breed-Specific Publications
Cadieu E, Neff MW, Quignon P, Walsh K, Chase K, Parker HG, Vonholdt BM, Rhue A, Boyko A, Byers A, Wong A, Mosher DS, Elkahloun AG, Spady TC, Andr?? C, Lark KG, Cargill M, Bustamante CD, Wayne RK, Ostrander EA. Coat variation in the domestic dog is governed

VHL Genetics

Link to GTP
Breed
ALL
OMIA
GTP Disease Name
Cu Locus (Curly Hair)
Gene Name
KRT71
Mutation
c.451C>T
Nature of test
mutation test

Wisdom Health (formerly Mars Veterinary)

Link to GTP
Breed
ALL
OMIA
GTP Disease Name
Cu Locus (Curly Hair)
Gene Name
KRT71
Mutation
c.451C>T
Nature of test
mutation test

GenSol Diagnostics

Link to GTP
Breed
ALL
OMIA
GTP Disease Name
Cu Locus (Curly Hair)
Gene Name
KRT71
Mutation
c.451C>T
GTP- or Breed-Specific Publications
Cadieu E, Neff MW, Quignon P, Walsh K, Chase K, Parker HG, Vonholdt BM, Rhue A, Boyko A, Byers A, Wong A, Mosher DS, Elkahloun AG, Spady TC, Andr?? C, Lark KG, Cargill M, Bustamante CD, Wayne RK, Ostrander EA. Coat variation in the domestic dog is governed
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