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Fanconi Syndrome

Breed: Basenji

Generic Phene Data

Breeds

Relevance Rating: The test is unknown, there is no evidence (i.e. research) available, or it has not been evaluated yet. These tests may or may not be meaningful in this breed

General

Disease Name
Fanconi Syndrome
Mutation
321bp deletion
Test Type
Genetic Disease/Disorder
Details
Fanconi syndrome causes the proximal renal tubules of the kidney to not properly reabsorb electrolytes and nutrients back into the body, but instead "spill" them in the urine. Symptoms include excessive drinking, excessive urination, and glucose in the urine. If Fanconi is left untreated, muscle wasting, acidosis, and poor condition will also occur. Age of onset on average between 4 and 8 years of age. Since the disease is typically not discovered until the dog is older, the condition is often passed on to offspring as it was not known that the parent was affected. Fanconi syndrome is progressive, and left untreated can be fatal.
Details 2
Fanconi syndrome causes the proximal renal tubules of the kidney to not properly reabsorb electrolytes and nutrients back into the body, but instead "spill" them in the urine. Symptoms include excessive drinking (polydipsia), excessive urination (polyuria), and glucose in the urine (glucosuria.) If Fanconi is left untreated, muscle wasting, acidosis, and poor condition will also occur.
Published
Farias, F.H.G. : Molecular genetic studies of canine inherited diseases. PhD thesis, University of Missouri http://hdl.handle.net/10355/14514 :, 2011.

Breed Specific Data

Wisdom Health (formerly Mars Veterinary)

GTP Name
Wisdom Health (formerly Mars Veterinary)
Breed
GTP Disease Name
Renal Fanconi syndrom
Gene Name
FAN1
Mutation
321bp deletion
Nature of test
mutation test
GTP- or Breed-Specific Publications
Carmichael, N., Lee, J., Giger, U. : Fanconi syndrome in dog in the UK. Vet Rec 174:357-8, 2014. Pubmed reference: 24700011. DOI: 10.1136/vr.g2554.
Inheritance
AR
FCI Number
43
GTP Breed
Basenji

Paw Print Genetics

GTP Name
Paw Print Genetics
Breed
GTP Disease Name
Renal Fanconi syndrom
Gene Name
FAN1
Mutation
321bp deletion
Nature of test
mutation test
FCI Number
43
GTP Breed
Basenji

Orthopedic Foundation for Animals

GTP Name
Orthopedic Foundation for Animals
Breed
GTP Disease Name
Renal Fanconi syndrom
Gene Name
FAN1
Mutation
321bp deletion
Nature of test
mutation test
GTP- or Breed-Specific Publications
Carmichael, N., Lee, J., Giger, U. : Fanconi syndrome in dog in the UK. Vet Rec 174:357-8, 2014. Pubmed reference: 24700011. DOI: 10.1136/vr.g2554.
Inheritance
AR
FCI Number
43
GTP Breed
Basenji

Laboklin Gmbh & Co. KG

GTP Name
Laboklin Gmbh & Co. KG
Breed
GTP Disease Name
Renal Fanconi syndrom
Gene Name
FAN1
Mutation
321bp deletion
Nature of test
mutation test
FCI Number
43

Genoscoper Laboratories Oy

GTP Name
Genoscoper Laboratories Oy
Breed
GTP Disease Name
Renal Fanconi syndrom
Gene Name
FAN1
Mutation
321bp deletion
Nature of test
mutation test
GTP- or Breed-Specific Publications
Carmichael, N., Lee, J., Giger, U. : Fanconi syndrome in dog in the UK. Vet Rec 174:357-8, 2014. Pubmed reference: 24700011. DOI: 10.1136/vr.g2554.
Application in the Breed
Inheritance
AR
FCI Number
43
GTP Breed
Basenji

Genomia s.r.o

GTP Name
Genomia s.r.o
Breed
GTP Disease Name
Renal Fanconi syndrom
Gene Name
FAN1
Mutation
321bp deletion
Nature of test
mutation test

EVG Diagnostics

GTP Name
EVG Molecular Diagnostics
Breed
Gene Name
FAN1
Mutation
c.2954-3271del
Nature of test
mutation test
GTP- or Breed-Specific Publications
Farias, F.H.G. : Molecular genetic studies of canine inherited diseases. PhD thesis, University of Missouri

Embark

GTP
GTP Name
Embark
Breed
GTP Disease Name
Renal Fanconi syndrom
Gene Name
FAN1
Mutation
321bp deletion
Nature of test
mutation test
GTP- or Breed-Specific Publications
Carmichael, N., Lee, J., Giger, U. : Fanconi syndrome in dog in the UK. Vet Rec 174:357-8, 2014. Pubmed reference: 24700011. DOI: 10.1136/vr.g2554.
Inheritance
AR
GTP Notes
Awaiting validation
FCI Number
43
GTP Breed
Basenji

CAG GmbH Center for Animal Genetics

GTP Name
Center for Animal Genetics
Breed
GTP Disease Name
Renal Fanconi syndrom
Gene Name
FAN1
Mutation
321bp deletion
Nature of test
mutation test
GTP- or Breed-Specific Publications
Carmichael, N., Lee, J., Giger, U. : Fanconi syndrome in dog in the UK. Vet Rec 174:357-8, 2014. Pubmed reference: 24700011. DOI: 10.1136/vr.g2554.
Inheritance
AR
FCI Number
43
GTP Breed
Basenji

Antagene

GTP
GTP Name
Antagene
Breed
GTP Disease Name
Renal Fanconi syndrom
Gene Name
FAN1
Mutation
321bp deletion
Nature of test
mutation test
FCI Number
43
GTP Breed
Basenji
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