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Factor VIII Deficiency

Breed: Boxer

Generic Phene Data

Breeds

Relevance Rating: The test is unknown, there is no evidence (i.e. research) available, or it has not been evaluated yet. These tests may or may not be meaningful in this breed

General

Disease Name
Factor VIII Deficiency
Mutation
c.1412C>G
Mutation 2
c.1643G>A
Mutation 3
p.Cys548Tyr
Test Type
Genetic Disease/Disorder
Details
Factor XIII deficiency causes an impaired coagulability of the blood, with a consequential strong tendency to bleed, due to a deficiency of clotting factor VIII. Since the gene for this factor is located on the X chromosome, the disorder is expected to be X-linked.
Details 2
Factor XIII deficiency causes an impaired coagulability of the blood, with a consequential strong tendency to bleed, due to a deficiency of clotting factor VIII. Since the gene for this factor is located on the X chromosome, the disorder is expected to be X-linked.
Published
Hough, C., Kamisue, S., Cameron, C., Notley, C., Tinlin, S., Giles, A., Lillicrap, D. : Aberrant splicing and premature termination of transcription of the FVIII gene as a cause of severe canine hemophilia A: Similarities with the intron 22 inversion mutation in human hemophilia Thrombosis & Haemostasis 87:659-665, 2002. Pubmed reference: 12008949.

Breed Specific Info

Researched Breeds
Boxer

Breed Specific Data

Genoscoper Laboratories Oy

GTP Name
Genoscoper Laboratories Oy
Breed
GTP Disease Name
Factor VIII Deficiency or Hemophilia A; mutation originally found in Old English Sheepdog
Gene Name
FVIII
Mutation
c.1643G>A; p.Cys548Tyr
Nature of test
mutation test
FCI Number
144
GTP Breed
Boxer

Laboklin Gmbh & Co. KG

GTP Name
Laboklin Gmbh & Co. KG
Breed
GTP Disease Name
Factor VIII Deficiency or Hemophilia A; mutation originally found in Old English Sheepdog
Gene Name
FVIII
Mutation
c.1412C>G
Nature of test
mutation test
FCI Number
144

Veterinary Genetics Laboratory

GTP Name
Veterinary Genetics Laboratory
Breed
GTP Disease Name
Factor VIII Deficiency or Hemophilia A; mutation originally found in Old English Sheepdog
Gene Name
FVIII
Mutation
c.1412C>G
Nature of test
mutation test

VHL Genetics

GTP Name
VHL Genetics
Breed
Gene Name
FVIII
Mutation
c.1412C>G; c.1643G>A; c.1643G>A

Wisdom Health (formerly Mars Veterinary)

GTP Name
Wisdom Health (formerly Mars Veterinary)
Breed
GTP Disease Name
Factor VIII Deficiency or Hemophilia A; mutation originally found in Old English Sheepdog
Gene Name
FVIII
Mutation
c.1643G>A; p.Cys548Tyr
Nature of test
mutation test
FCI Number
144
GTP Breed
Boxer

Certagen GmbH

GTP Name
Certagen GmbH
Breed
Gene Name
FVIII
Mutation
c.1412C>G; c.1643G>A; c.1643G>A

Agrotis S.r.l.

GTP Name
Agrotis S.r.l.
Breed
Gene Name
FVIII
Mutation
c.1412C>G; c.1643G>A; c.1643G>A

BioBank AS

GTP Name
BioBank AS
Breed
Gene Name
FVIII
Mutation
c.1412C>G; c.1643G>A; c.1643G>A

CMSCH

GTP
GTP Name
CMSCH
Breed
Gene Name
FVIII
Mutation
c.1412C>G; c.1643G>A; c.1643G>A

INNO

GTP
GTP Name
INNO
Breed
Gene Name
FVIII
Mutation
c.1412C>G; c.1643G>A; c.1643G>A

Laboratorios Labocor S.L.

GTP Name
Laboratorios Labocor S.L.
Breed
Gene Name
FVIII
Mutation
c.1412C>G; c.1643G>A; c.1643G>A

PharmaDNA

GTP
GTP Name
PharmaDNA
Breed
Gene Name
FVIII
Mutation
c.1412C>G; c.1643G>A; c.1643G>A

Progènes-ADN

GTP Name
Progenes ADN
Breed
Gene Name
FVIII
Mutation
c.1412C>G; c.1643G>A; c.1643G>A

Zoolyx

GTP
GTP Name
Zoolyx
Breed
Gene Name
FVIII
Mutation
c.1412C>G; c.1643G>A; c.1643G>A
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