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Factor VIII Deficiency

Breed: German shepherd dog/ Long and harsch outer coat

Generic Phene Data

Breeds

Relevance Rating: The test is unknown, there is no evidence (i.e. research) available, or it has not been evaluated yet. These tests may or may not be meaningful in this breed

General

Disease Name
Factor VIII Deficiency
Mutation
c.1412C>G
Mutation 2
c.1643G>A
Test Type
Genetic Disease/Disorder
Details
Factor XIII deficiency causes an impaired coagulability of the blood, with a consequential strong tendency to bleed, due to a deficiency of clotting factor VIII. Since the gene for this factor is located on the X chromosome, the disorder is expected to be X-linked.
Details 2
Factor XIII deficiency causes an impaired coagulability of the blood, with a consequential strong tendency to bleed, due to a deficiency of clotting factor VIII. Since the gene for this factor is located on the X chromosome, the disorder is expected to be X-linked.
Published
Hough, C., Kamisue, S., Cameron, C., Notley, C., Tinlin, S., Giles, A., Lillicrap, D. : Aberrant splicing and premature termination of transcription of the FVIII gene as a cause of severe canine hemophilia A: Similarities with the intron 22 inversion mutation in human hemophilia Thrombosis & Haemostasis 87:659-665, 2002. Pubmed reference: 12008949.

Breed Specific Data

Agrotis S.r.l.

GTP Name
Agrotis S.r.l.
Gene Name
FVIII
Mutation
c.98G>A; c.1412C>G; c.1643G>A; c.1643G>A

BioBank AS

GTP Name
BioBank AS
Gene Name
FVIII
Mutation
c.98G>A; c.1412C>G; c.1643G>A; c.1643G>A

Certagen GmbH

GTP Name
Certagen GmbH
Gene Name
FVIII
Mutation
c.98G>A; c.1412C>G; c.1643G>A; c.1643G>A

CMSCH

GTP
GTP Name
CMSCH
Gene Name
FVIII
Mutation
c.98G>A; c.1412C>G; c.1643G>A; c.1643G>A

Genoscoper Laboratories Oy

GTP Name
Genoscoper Laboratories Oy
GTP Disease Name
Factor VIII Deficiency or Hemophilia A; mutation originally found in Old English Sheepdog
Gene Name
FVIII
Mutation
c.1643G>A; p.Cys548Tyr
Nature of test
mutation test
FCI Number
166
GTP Breed
German Shepherd Dog - Longhaired

INNO

GTP
GTP Name
INNO
Gene Name
FVIII
Mutation
c.98G>A; c.1412C>G; c.1643G>A; c.1643G>A

Laboratorios Labocor S.L.

GTP Name
Laboratorios Labocor S.L.
Gene Name
FVIII
Mutation
c.98G>A; c.1412C>G; c.1643G>A; c.1643G>A

Laboklin Gmbh & Co. KG

GTP Name
Laboklin Gmbh & Co. KG
GTP Disease Name
Factor VIII Deficiency or Hemophilia A; mutation originally found in Old English Sheepdog
Gene Name
FVIII
Mutation
c.1412C>G
Nature of test
mutation test
FCI Number
166

Paw Print Genetics

GTP Name
Paw Print Genetics
GTP Disease Name
Factor VIII Deficiency or Hemophilia A; mutation originally found in Old English Sheepdog
Gene Name
FVIII
Mutation
c.1643G>A; p.Cys548Tyr
Nature of test
mutation test
FCI Number
166

PharmaDNA

GTP
GTP Name
PharmaDNA
Gene Name
FVIII
Mutation
c.98G>A; c.1412C>G; c.1643G>A; c.1643G>A

Progènes-ADN

GTP Name
Progenes ADN
Gene Name
FVIII
Mutation
c.98G>A; c.1412C>G; c.1643G>A; c.1643G>A

Veterinary Genetics Laboratory

GTP Name
Veterinary Genetics Laboratory
GTP Disease Name
Factor VIII Deficiency or Hemophilia A; mutation originally found in Old English Sheepdog
Gene Name
FVIII
Mutation
c.98G>A
Nature of test
mutation test

VHL Genetics

GTP Name
VHL Genetics
Gene Name
FVIII
Mutation
c.98G>A; c.1412C>G; c.1643G>A; c.1643G>A

Wisdom Health (formerly Mars Veterinary)

GTP Name
Wisdom Health (formerly Mars Veterinary)
GTP Disease Name
Factor VIII Deficiency or Hemophilia A; mutation originally found in Old English Sheepdog
Gene Name
FVIII
Mutation
c.1643G>A; p.Cys548Tyr
Nature of test
mutation test
FCI Number
166
GTP Breed
German Shepherd Dog - Longhaired

Zoolyx

GTP
GTP Name
Zoolyx
Gene Name
FVIII
Mutation
c.98G>A; c.1412C>G; c.1643G>A; c.1643G>A
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