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Nephropathy

General

Disease Name
Nephropathy
Mutation
c.115A>T
Mutation 2
c.2712C>T
Test Type
Genetic Disease/Disorder
Details
Familial Nephropathy (FN) is a disease of the kidneys, found in a number of breeds and breed types. Sypmtoms and age of onset can vary by breed. Signs include kidney stones, bloody urine, protein loss into urine, hypertension, anorexia, vomiting, weight loss, build-up of fluid in tissues, abnormal behaviour, adverse reactions to specific foods leading to diarrhea and itchy skin. Age of first signs/onset 2 ? 6 years. If undiagnosed, can lead to fatal kidney failure without prompt treatment.
Details 2
Familial Nephropathy (FN) is a disease of the kidneys, found in a number of breeds and breed types. Sypmtoms and age of onset can vary by breed. Signs include kidney stones, bloody urine, protein loss into urine, hypertension, anorexia, vomiting, weight loss, build-up of fluid in tissues, abnormal behaviour, adverse reactions to specific foods leading to diarrhea and itchy skin. Age of first signs/onset 2 ? 6 years. If undiagnosed, can lead to fatal kidney failure without prompt treatment.
Published
Davidson, AG., Bell, RJ., Lees, GE., Kashtan, CE., Davidson, GS., Murphy, KE. : Genetic cause of autosomal recessive hereditary nephropathy in the English Cocker Spaniel. J Vet Intern Med 21:394-401, 2007. Pubmed reference: 17552442.
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