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Gastrointestinal Stromal Tumor
General
Disease Name
Gastrointestinal Stromal Tumor
OMIA
1516
Gene Name
KIT
Mutation
g.50110841_50110846delGGAAGG
Mutation 2
g.50110838_50110843delAGTGGA
Test Type
Genetic Disease/Disorder
Details
Primary gastrointestinal (GI) mesenchymal neoplasms in the dog include histologically similar entities such as leiomyomas, leiomyosarcomas, and gastrointestinal stromal tumors (GISTs)...Canine GISTs usually occur in older dogs, most commonly in the small intestine and colon...The clinical behavior of canine GISTs ranges from benign to malignant with metastases to the liver, spleen, mesentery, or mesenteric lymph nodes. (Gillespie et al, 2011)
Details 2
Primary gastrointestinal (GI) mesenchymal neoplasms in the dog include histologically similar entities such as leiomyomas, leiomyosarcomas, and gastrointestinal stromal tumors (GISTs)...Canine GISTs usually occur in older dogs, most commonly in the small intestine and colon...The clinical behavior of canine GISTs ranges from benign to malignant with metastases to the liver, spleen, mesentery, or mesenteric lymph nodes. (Gillespie et al, 2011)
Published
Gregory-Bryson, E., Bartlett, E., Kiupel, M., Hayes, S., Yuzbasiyan-Gurkan, V. : Canine and human gastrointestinal stromal tumors display similar mutations in c-KIT exon 11. BMC Cancer 10:559, 2010. Pubmed reference: 20950418. DOI: 10.1186/1471-2407-10-559.
Published 2
Takanosu, M., Amano, S., Kagawa, Y. : Analysis of c-KIT exon 11 mutations in canine gastrointestinal stromal tumours. Vet J 207:118-23, 2016. Pubmed reference: 26631948. DOI: 10.1016/j.tvjl.2015.10.051.
Published 3
V. Gillespie, K. Baer, J. Farrelly, D. Craft, and R. Luong, Veterinary Pathology, 48(1) 283-291, The American College of Veterinary Pathologists, 2011, DOI: 10.1177/0300985810380397
Body/System/Process
Gastrointestinal
OMIA Url
Inheritance
A
