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Nephritis, X-linked

Breeds

Relevance Rating: The test is unknown, there is no evidence (i.e. research) available, or it has not been evaluated yet. These tests may or may not be meaningful for these breeds

General

Disease Name
Nephritis, X-linked
Mutation
c.3079G>T
Test Type
Genetic Disease/Disorder
Details
X-linked nephritis is a disorder of the kidneys affecting dogs causing protein filterd by the kidneys from blood to be lost in the urine. Signs include: abnormal amounts of protein detected in urine, dogs are smaller and thinner, progressing to chronic kidney failure. Signs of kidney failure include increased and excessive thirst and urination, vomiting, anorexia, weight loss, weakness and fatigue. Age of onset from 2-3 months, signs of kidney failure between 7-15 months. Due to its X-linked recessive inheritance, male dogs are more frequently affected with this disease than female dogs. Female dogs may be less affected by this disorder. Affected dogs with kidney failure die or are euthanised by 12-18 months of age on average.
Details 2
X-linked nephritis is a disorder of the kidneys affecting dogs causing protein filterd by the kidneys from blood to be lost in the urine. Signs include: abnormal amounts of protein detected in urine, dogs are smaller and thinner, progressing to chronic kidney failure. Signs of kidney failure include increased and excessive thirst and urination, vomiting, anorexia, weight loss, weakness and fatigue. Age of onset from 2-3 months, signs of kidney failure between 7-15 months. Due to its X-linked recessive inheritance, male dogs are more frequently affected with this disease than female dogs. Female dogs may be less affected by this disorder. Affected dogs with kidney failure die or are euthanised by 12-18 months of age on average.
Published
Zheng, K.Q., Thorner, P.S., Marrano, P., Baumal, R., Mcinnes, R.R. : Canine X Chromosome-Linked Hereditary Nephritis - A Genetic Model for Human X-Linked Hereditary Nephritis Resulting from a Single Base Mutation in the Gene Encoding the alpha 5 Chain of Collagen Type IV Proceedings of the National Academy of Sciences of the United States of America 91:3989-3993, 1994. Pubmed reference: 8171024.
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