Anal Furunculosis
General
Disease Name
Anal Furunculosis
OMIA
1589
Gene Name
unknown
Mutation
unknown
Mutation 2
HLA DRB1 00101 allele
Test Type
Genetic Disease/Disorder
Details
Dogs with anal furunculosis have a long-term progressive disease of the skin and underlying tissues which causes inflammation, skin ulceration, deep cavities and channels through the skin around the anus. The surface of the skin and the ulcers in the area around the anus are often covered by pus. Defaecation becomes difficult due to the pain felt by the dog while trying to pass faeces. Age of onset varies, but usually noticed at maturity. It is a chronic condition which can cause moderate to severe irritation and pain, especially at defaecation. There is some evidence that it may be due to an underlying abnormality of the immune system and/or the abnormal tail conformation and carriage.
Details 2
Dogs with anal furunculosis have a long-term progressive disease of the skin and underlying tissues which causes inflammation, skin ulceration, deep cavities and channels through the skin around the anus. The surface of the skin and the ulcers in the area around the anus are often covered by pus. Defaecation becomes difficult due to the pain felt by the dog while trying to pass faeces. Age of onset varies, but usually noticed at maturity. It is a chronic condition which can cause moderate to severe irritation and pain, especially at defaecation. There is some evidence that it may be due to an underlying abnormality of the immune system and/or the abnormal tail conformation and carriage.
Published
Massey, J., Short, A.D., Catchpole, B., House, A., Day, M.J., Lohi, H., Ollier, W.E., Kennedy, L.J. : Genetics of canine anal furunculosis in the German shepherd dog. Immunogenetics :, 2014. Pubmed reference: 24626934. DOI: 10.1007/s00251-014-0766-5.
Published 2
House, AK., Binns, MM., Gregory, SP., Catchpole, B. : Analysis of NOD1, NOD2, TLR1, TLR2, TLR4, TLR5, TLR6 and TLR9 genes in anal furunculosis of German shepherd dogs. Tissue Antigens 73:250-4, 2009. Pubmed reference: 19254256. DOI: 10.1111/j.1399-0039.2008.01190.x.
Published 3
Barnes, A., O'Neill, T., Kennedy, LJ., Short, AD., Catchpole, B., House, A., Binns, M., Fretwell, N., Day, MJ., Ollier, WE. : Association of canine anal furunculosis with TNFA is secondary to linkage disequilibrium with DLA-DRB1*. Tissue Antigens 73:218-24, 2009. Pubmed reference: 19254251. DOI: 10.1111/j.1399-0039.2008.01188.x.
Body/System/Process
Gastrointestinal
OMIA Url
Inheritance
unknown
Breed Specific Info
Researched Breeds
German Shepherd