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Renal Cystadenocarcinoma and Nodular Dermatofibrosis


Relevance Rating: There is some evidence or research available in this breed

Relevance Rating: The test is unknown, there is no evidence (i.e. research) available, or it has not been evaluated yet. These tests may or may not be meaningful for these breeds


Disease Name
Renal Cystadenocarcinoma and Nodular Dermatofibrosis
Test Type
Genetic Disease/Disorder
Renal Cystadenocarcinoma and Nodular Dermatofibrosis causes a predisposition to kidney cancer. This condition manifests as a combination of abnormal masses in the kidneys. Owners tend to notice small, hard bumps on thier dog, and signs of kidney disease such as drinking more, frequent urination, blood in the urine, depression, and anorexia. Age of onset around 5-7 years of age, or much older.
Details 2
The disease is characterized by bilateral, multifocal tumors in the kidneys, uterine leiomyomas and nodules in the skin consisting of dense collagen fibers. (Lingaas et al, 2003)
Lingaas, F., Comstock, K.E., Kirkness, E.F., Sørensen, A., Aarskaug, T., Hitte, C., Nickerson, M.L., Moe, L., Schmidt, L.S., Thomas, R., Breen, M., Galibert, F., Zbar, B., Ostrander, E.A. : A mutation in the canine BHD gene is associated with hereditary multifocal renal cystadenocarcinoma and nodular dermatofibrosis in the German Shepherd dog. Hum Mol Genet 12:3043-53, 2003. Pubmed reference: 14532326. DOI: 10.1093/hmg/ddg336.
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