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Neonatal Encephalopathy with Seizures


Relevance Rating: There is some evidence or research available for these breeds

Relevance Rating: The test is unknown, there is no evidence (i.e. research) available, or it has not been evaluated yet. These tests may or may not be meaningful for these breeds


Disease Name
Neonatal Encephalopathy with Seizures
Test Type
Genetic Disease/Disorder
Puppies affected by Neonatal Encephalopathy with Seizures are small at birth and do not develop normally - initially struggling to nurse. Nursing improves after several days, but at around 3 weeks of age, signs include: weakness, ataxia, whole-body tremors, wide-based stance, and muscle weakness. Pups do not interact normally with the dam or littermates and have slow responses to stimulation. Sympotoms change at 4 to 6 weeks of age to include generalized seizures. Pups usually die or are euthanized by 7 weeks of age.
Details 2
Affected puppies are small at birth and do not develop normally. They initially nurse poorly, but begin nursing sufficiently after several days... At approximately 3 weeks of age, weakness, ataxia, whole-body tremors, wide-based stance with increased extensor tone, and axial muscle weakness with neck ventroflexion is observed. Affected pups do not interact with the dam or littermates and have slow responses to external stimuli... At approximately 4 to 6 weeks of age, affected puppies develop generalized clonic-tonic seizures that quickly become refractory to treatment. They become laterally recumbent with extensor rigidity and opisthotonus, and usually die or are euthanized before 7 weeks of age (Chen et al., 2008).
Chen, X., Johnson, GS., Schnabel, RD., Taylor, JF., Johnson, GC., Parker, HG., Patterson, EE., Katz, ML., Awano, T., Khan, S., O'Brien, DP. : A neonatal encephalopathy with seizures in standard poodle dogs with a missense mutation in the canine ortholog of ATF2. Neurogenetics 9:41-9, 2008. Pubmed reference: 18074159. DOI: 10.1007/s10048-007-0112-2.
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