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Metabolizer of a Cognitive Enhancer
General
Disease Name
Metabolizer of a Cognitive Enhancer
OMIA
1405
Gene Name
CYP1A2
Mutation
c.1117C>T
Mutation 2
p. R373*
Mutation 3
g.37821686
Test Type
Other Genetic Traits
Details
Appears to have a use for veterinary and pharmalogical purposes only. Influences if a dog is an extensive metabolizers or poor metabolizers.
Details 2
Appears to have a use for veterinary and pharmalogical purposes only. Influences if a dog is an extensive metabolizers or poor metabolizers.
Published
Tenmizu, D., Endo, Y., Noguchi, K., Kamimura, H. : Identification of the novel canine CYP1A2 1117 C > T SNP causing protein deletion. Xenobiotica 34:835-46, 2004. Pubmed reference: 15742977. DOI: 10.1080/00498250412331285436.
Published 2
Mise, M., Yadera, S., Matsuda, M., Hashizume, T., Matsumoto, S., Terauchi, Y., Fujii, T. : Polymorphic expression of CYP1A2 leading to interindividual variability in metabolism of a novel benzodiazepine receptor partial inverse agonist in dogs. Drug Metab Dispos 32:240-5, 2004. Pubmed reference: 14744947. DOI: 10.1124/dmd.32.2.240.
Published 3
Mise, M., Hashizume, T., Matsumoto, S., Terauchi, Y., Fujii, T. : Identification of non-functional allelic variant of CYP1A2 in dogs. Pharmacogenetics 14:769-73, 2004. Pubmed reference: 15564884.
Published 4
Tenmizu, D., Noguchi, K., Kamimura, H. : Elucidation of the effects of the CYP1A2 deficiency polymorphism in the metabolism of 4-cyclohexyl-1-ethyl-7-methylpyrido[2,3-d]pyrimidine-2-(1h)-one (YM-64227), a phosphodiesterase type 4 inhibitor, and its metabolites in dogs. Drug Metab Dispos 34:1811-6, 2006. Pubmed reference: 16882764. DOI: 10.1124/dmd.106.011213.
Body/System/Process
Metabolic
OMIA Url
Inheritance
unknown
Breed Specific Info
Researched Breeds
Beagle
