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Progressive Retinal Atrophy crd3 (PRA crd3)


Relevance Rating: Unknown, not evaluated or no evidence for test in this breed


Disease Name
Progressive Retinal Atrophy crd3 (PRA crd3)
Test Type
Genetic Disease/Disorder
PRA crd3 is one of several cone rod dystrophies (crd) that have been recognised and is caused by a recessive mutation. All forms of crd are characterised by the initial loss of cones, the cells in the retina that are responsible for vision in bright light/day light, followed by the degeneration of rods, the retinal cells that operate during night vision. Clinical effects of crd3 are usually not evident until two years of age, but in some instances may be delayed until aged seven or older.
Details 2
A variable and, at times, very late onset of gPRA caused by a crd form, is unique as a relatively mild retinal degeneration at advanced age (2-7 years, sometimes later).
Kropatsch, R., Petrasch-Parwez, E., Seelow, D., Schlichting, A., Gerding, WM., Akkad, DA., Epplen, JT., Dekomien, G. : Generalized progressive retinal atrophy in the Irish Glen of Imaal Terrier is associated with a deletion in the ADAM9 gene. Mol Cell Probes 24:357-63, 2010. Pubmed reference: 20691256. DOI: 10.1016/j.mcp.2010.07.007.
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