Reminder: Login to access new features and members-only content!

Register to be a member of our community. Its easy!

Register a new account

Already a member?

Log In here!


Did you find our content interesting or helpful? Help support the IPFD enhance health, well-being and welfare for dogs everywhere.

Jump to content
  •   Language
  • Sign Up

International Partnership for Dogs - Enhancing Dog Health, Well-Being, and Welfare - Join Us.

May-Hegglin Anomaly


Relevance Rating: The test is unknown, there is no evidence (i.e. research) available, or it has not been evaluated yet. These tests may or may not be meaningful for these breeds



Disease Name
May-Hegglin Anomaly
Test Type
Genetic Disease/Disorder
May-Hegglin Anomaly is considered to be a rare. This disorder of platelet formation is sometimes mistaken for immune-mediated thrombocytopenia. Symptoms include: low platelet count, "enlarged" platelets, and changes in neutrophils - causing prolonged bleeding time and bruising.
Details 2
An 8-year-old female spayed Pug dog was presented for evaluation of cutaneous lesions occurring secondary to immunosuppressive treatment of presumed immune-mediated thrombocytopenia. Abnormal hematologic findings included persistent thrombocytopenia, macrothrombocytes, and variably shaped, often fusiform, blue cytoplasmic inclusions in neutrophils. May-Hegglin anomaly (MHA) was suspected based on the morphologic appearance of platelets and neutrophils. Examination of cells by transmission electron microscopy revealed normal platelet ultrastructure; neutrophil inclusions had features similar to those reported for inclusions in human MHA. Neutrophil function was within normal limits based on flow cytometric analysis. Thrombelastography indicated a prolonged clotting time (r), and PlateletMapping showed a lack of response to 2 ?M ADP compared with a moderate response in the control dog... (From Flatland et al, 2011)
Flatland, B., Fry, M.M., Baek, S.J., Bahn, J.H., LeBlanc, C.J., Dunlap, J.R., Carroll, R.C., Kosiba, D.J., Millsaps, D.J., Schleis, S.E. : May-Hegglin anomaly in a dog. Vet Clin Pathol 40:207-14, 2011. Pubmed reference: 21554370. DOI: 10.1111/j.1939-165X.2011.00320.x.
  • Create New...

Important Information

By using this site, you agree to our Terms of Use.