Disease Name 2
Familial Enamel Hypoplasia
Familial Enamel Hypoplasia, FEH
The disease is caused by a thinning or absent outer enamel layer with irregular pitting, paired with with patchy tooth discoloration. Owners report teeth appearing smaller, and having a "rough" texture with dark patches. Dogs can experience sensitivity, tooth wear, tartar, gingivitis, bad breath, and periodontal diseases leading to tooth loss and gum problems. Age of onset when the permanent teeth erupt, around 5-6 months of age (varying slightly by breed).
The disease is characterized by a thinning or absent outer enamel layer with irregular pitting. Appearing with patchy tooth discoloration, sensitivity, tooth wear, tartar, gingivitis and periodontitis. All in all, can cause a "rough" texture and "dark patches" on the teeth. Age of onset when the permanent teeth erupt, around 5-6 months of age (varying slightly by breed). Associated periodontal disease can lead to bone loss, gum recession and tooth loss. Halitosis is also common.
Gandolfi, B., Liu, H., Griffioen, L., Pedersen, N.C. : Simple recessive mutation in ENAM is associated with amelogenesis imperfecta in Italian Greyhounds. Anim Genet 44:569-78, 2013. Pubmed reference: 23638899. DOI: 10.1111/age.12043.
Pedersen, N.C., Shope, B., Liu, H. : An autosomal recessive mutation in SCL24A4 causing enamel hypoplasia in Samoyed and its relationship to breed-wide genetic diversity. Canine Genet Epidemiol 4:11, 2017. Pubmed reference: 29201383. DOI: 10.1186/s40575-017-0049-1.
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