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Progressive Retinal Atrophy, Type B
Breeds
Relevance Rating: There is some evidence or research available in this breed
General
Disease Name
Progressive Retinal Atrophy, Type B
OMIA
-36
Gene Name
unpublished
Mutation
unpublished
Test Type
Genetic Disease/Disorder
Details
PRA Type B identifies a risk variant for the disease. (i.e. it is not a definative yes/no risk answer, but may aid in identifying at-risk or low-risk dogs). The Type B PRA test results are reported as causal or "risk variant", because, although dogs carrying two copies of the variant are very likely to develop PRA, a percentage of the research sample set that were homozygous for the variant did not develop PRA by 7 years of age. Owners and breeders using a test for this disease should review breeding guidance from the test provider or a specialist.
Details 2
PRA: Type B identifies a risk variant for the disease. (i.e. it is not a definative yes/no risk answer, but may aid in identifying at-risk or low-risk dogs). The Type B PRA test results are reported as causal or "risk variant, because, although dogs carrying two copies of the variant are very likely to develop PRA, a percentage of the research sample set that were homozygous for the variant did not develop PRA by 7 years of age. It is not clear at this time whether the variant represents a causal mutation ?and that other factors influence the ?penetrance? of the mutation.
Body/System/Process
Eye
Inheritance
RV
Breed Specific Info
Researched Breeds
Miniature Schnauzer
