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Dermatomyositis

Breeds

Relevance Rating: Unknown, not evaluated or no evidence for test for these breeds

General

Disease Name
Dermatomyositis
Gene Name 2
MAP3K7CL
Mutation
p.Arg492Cys
Mutation 2
c.383_392ACTCCACAAA>GACT, DLA-DRB1*002:01
Test Type
Genetic Disease/Disorder
Details
Dermatomyositis (DMS) is an autoimmune disease of the skin and muscle. Symptoms include skin lesions, hair loss and crusts on the face, ear tips, legs and feet, and the tip of the tail. In some breeds, additional symptoms include muscle wasting, difficulty swallowing, and an unusual gait. Age of onset varies, from as early as 12 weeks to mature dogs.The causes of the disease are multifactorial - a combination of genetic and environmental factors. Tests for this disease determine a number of risk alleles. The combination of the presence of the risk alleles indicate risk only.
Details 2
Dermatomyositis (DMS) is an autoimmune disease of the skin and muscle. Symptoms include skin lesions, hair loss and crusts on the face, ear tips, legs and feet, and the tip of the tail. In some breeds, additional symptoms include muscle wasting, difficulty swallowing, and an unusual gait. Age of onset varies, from as early as 12 weeks to mature dogs.The causes of the disease are multifactorial - a combination of genetic and environmental factors. Tests for this disease determine a number of risk alleles. The combination of the presence of the risk alleles indicate risk only.
Published
Evans JM, Noorai RE, Tsai KL, Starr-Moss AN, Hill CM, Anderson KJ, et al. (2017) Beyond the MHC: A canine model of dermatomyositis shows a complex pattern of genetic risk involving novel loci. PLoS Genet 13(2) e1006604.doi:10.1371/journal.pgen.1006604
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