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Dermoid Sinus

General

Disease Name
Dermoid Sinus
Mutation
large duplication
Test Type
Genetic Disease/Disorder
Details
The dominant inheritance of the "ridge" of hair typical of the Rhodesian Ridgeback breed means that dogs with either a single or double copy of the genes will appear the same, with the ridge of hair. However, those dogs homozygous (2 copies) of the gene are at a increased likelyhood to also develop a dermoid sinus. Age of onset is from birth. Symptoms can vary depending on the dermoid sinus location, and if it develops infection. Problems can include: discharge, infection, abscess, neurological problems.
Details 2
The dominant inheritance of the "ridge" of hair typical of the Rhodesian Ridgeback breed means that dogs with either a single or double copy of the genes will appear the same, with the ridge of hair. However, those dogs homozygous (2 copies) of the gene are at a increased likelyhood to also develop a dermoid sinus. Age of onset is from birth. Symptoms can vary depending on the dermoid sinus location, and if it develops infection. Problems can include: discharge, infection, abscess, neurological problems.
Published
Salmon Hillbertz, N.H., Isaksson, M., Karlsson, E.K., Hellmén, E., Pielberg, G.R., Savolainen, P., Wade, C.M., von Euler, H., Gustafson, U., Hedhammar, A., Nilsson, M., Lindblad-Toh, K., Andersson, L., Andersson, G. : Duplication of FGF3, FGF4, FGF19 and ORAOV1 causes hair ridge and predisposition to dermoid sinus in Ridgeback dogs. Nat Genet 39:1318-20, 2007. Pubmed reference: 17906623. DOI: 10.1038/ng.2007.4.
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