ACTH-independent Adrenal Cushing Syndrome
General
Disease Name
ACTH-independent Adrenal Cushing Syndrome
OMIA
1937
Gene Name
GNAS
Mutation
NC_006606.3 (43643409..43658641)
Test Type
Genetic Disease/Disorder
Details
The disease develops slowly and the early signs are not always noticed. Symptoms in dogs include: increased thirst, urination, and appetite. Dogs may have reduced activity, and excessive panting. Cushing's disease typically occurs in middle-aged to older dogs.
Published
Kool, M.M., Galac, S., Spandauw, C.G., Kooistra, H.S., Mol, J.A. : Activating mutations of GNAS in canine cortisol-secreting adrenocortical tumors. J Vet Intern Med 27:1486-92, 2013. Pubmed reference: 24112376. DOI: 10.1111/jvim.12194.
Body/System/Process
Endocrine
OMIA Url
Inheritance
unknown