1. To reveal if there is sufficient phenotypic and genotypic variation in four brachycephalic breeds to allow selection to achieve a change in anatomy to reduce the predisposition for Brachycephalic Obstructive Airway Syndrome (BOAS)
2. To indicate breeding animals that by fitness and morphological features would enhance the health in these breeds.
3. To relate phenotypic measures to underlying genetic factors
MATERIALS AND METHODS
The project is based on “Breed” - gatherings - arranged for by the breed clubs – and supported by the national Kennel Clubs
At 2-4 gatherings per breed and country and as many individuals as possible in these breeds are aimed to reach at various locations in Denmark, Finland, Norway and Sweden. These breed gatherings are aimed to attract registered as well as non-registered individuals nationally and internationally obtained to reflect the within breed variations.
One to three show judges (or with comparable competence) and 1-3 veterinarians are to be recruited to perform the phenotypic description of each participating dog. Students and breed club members are recruited to assist in measurements and documentation. A form for reporting and a form to be handed out will be developed.
It is essential that the event is meant to describe and not to rank the participating dogs.
It is however crucial to plan for how to best inform and advice the owner if their dog is evaluated to suffer from BOAS.
Information to be gathered
1. data by breed on
a) Demography: gender, age, country of origin, registration number or not
b) Measures of weight, BodyConditionScore (BCS) and conformational measurements (i.e. width of Nares (WN), craniofacial ratio (CFR), neck girth ratio (NGR).
c) Photo in standardised position (whole body and Skull)
c) General and specific health conditions by surveying owners
d) A veterinary examination (clinical data including BOAS)
c) and d) will follow the procedure at the examination of adult dogs for BOAS except/ before the provocation by exercise (link to the form with instructions)
2. samples for genomic analyses
Cheek swabs will be obtained from each dog for molecular genetic studies
a) SNP-array genotyping of around 400 dogs as described above
a) By analyses of data it is intended to compare variations within and between breeds for age, gender, origin and the indicated measures – Body weight, Body Condition Score (BCS) and conformational measurements (i.e. width of Nares (WN), craniofacial ratio (CFR), neck girth ratio (NGR).
to relate it to clinical data and the data from the molecular genetic studies
b) By indication of favourable phenotypes and genotypes it is intended to influence the selection of breeding stock in these breeds
The full document "REVEALING THE PHENOTYPIC AND GENOTYPIC VARIATION IN FOUR BRACHYCEPHALIC BREEDS (SKK)" is available. Contact us.