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Craniomandibular Osteopathy

Breed: English Foxhound

Breeds

Relevance Rating: The test is unknown, there is no evidence (i.e. research) available, or it has not been evaluated yet. These tests may or may not be meaningful for these breeds

General

Disease Name
Craniomandibular Osteopathy
Mutation
c.1332C>T
Test Type
Genetic Disease/Disorder
Details
Craniomandibular Osteopathy (CMO) is a disease causing extensive developmental changes in the bones of the skull and jaw. Symptoms include hard swelling and thickening of the jaw to the point of the mouth cannot fully open, drooling, severe pain and reoccuring tenderness, and difficulty eating. Treatment is limited to managing the symptoms. Inability to eat can cause malnutrition, and this, coupled with pain or difficulty with treatment can lead to a dog being euthanised.
Details 2
A four-month-old West Highland White Terrier was presented to the Small Animal Teaching Hospital at the University of Liverpool with the complaint of a bilateral angular carpal deformity. A 20° valgus deformity was present in both thoracic limbs, centred on the distal radial physes. Both distal ulnas were grossly thickened and there was concomitant thickening of the rostral mandible and calvarium. The dog exhibited signs of resentment on palpation of the mandible and signs of pain were elicited on flexion and extension of both elbow joints. No signs of pain were evident on palpation of the ulnas or calvarium. Radiographic images of both ulnas showed marked amorphous periosteal new bone formation. The distal ulnar physes were closed centrally and both elbow joints had humeroulnar subluxation. Radiographic changes to the calvarium and mandibular rami were consistent with a diagnosis of craniomandibular osteopathy. A bilateral ulna ostectomy was performed to correct the angular limb deformity and elbow subluxations. Histology of the ostectomised pieces showed changes consistent with craniomandibular osteopathy. (Pettitt et al, 2012)
Published
Pettitt, R., Fox, R., Comerford, E.J., Newitt, A. : Bilateral angular carpal deformity in a dog with craniomandibular osteopathy. Vet Comp Orthop Traumatol 25:149-54, 2012. Pubmed reference: 22366888. DOI: 10.3415/VCOT-11-02-0022.
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