Donate
Coat Colour, Agouti
Breed: ALL
Generic Phene Data
Breeds
Relevance Rating: The test is unknown, there is no evidence (i.e. research) available, or it has not been evaluated yet. These tests may or may not be meaningful in this breed
GTPs
General
Disease Name
Coat Colour, Agouti
OMIA
201
Gene Name
ASIP
Mutation
c.244G>T
Mutation 2
p.A82S
Mutation 3
c.248G>A
Mutation 4
p.R83H
Mutation 5
c.286C>T
Mutation 6
p.R96C
Test Type
Other Genetic Traits
Details
Agouti consists of four alleles: sable (Ay), agouti (aw), tan points (at), recessive black (a). Agouti alleles control which cells produce eumelanin (black or modified black pigment) and, for (aw), when. Please note that a dominant black dog may be genetically a sable, tan-point or agouti, but it will not be able to display it. In some breeds it's thought that the A locus genes may display incomplete dominance, with the appearance of the dog being affected by its more recessive allele as well as the more dominant one.
Details 2
Agouti consists of four alleles: sable (Ay), agouti (aw), tan points (at), recessive black (a). Agouti alleles control which cells produce eumelanin (black or modified black pigment) and, for (aw), when. Please note that a dominant black dog may be genetically a sable, tan-point or agouti, but it will not be able to display it. In some breeds it's thought that the A locus genes may display incomplete dominance, with the appearance of the dog being affected by its more recessive allele as well as the more dominant one.
Published
Kerns, JA., Newton, J., Berryere, TG., Rubin, EM., Cheng, JF., Schmutz, SM., Barsh, GS. : Characterization of the dog Agouti gene and a nonagoutimutation in German Shepherd Dogs. Mamm Genome 15:798-808, 2004. Pubmed reference: 15520882. DOI: 10.1007/s00335-004-2377-1.
Published 2
Dreger, D.L., Schmutz, S.M. : A SINE Insertion Causes the Black-and-Tan and Saddle Tan Phenotypes in Domestic Dogs. J Hered :S11-8, 2011. Pubmed reference: 21846741. DOI: 10.1093/jhered/esr042.
Published 3
Dreger, D.L., Parker, H.G., Ostrander, E.A., Schmutz, S.M. : Identification of a mutation that is associated with the saddle tan and black-and-tan phenotypes in Basset Hounds and Pembroke Welsh Corgis. J Hered 104:399-406, 2013. Pubmed reference: 23519866. DOI: 10.1093/jhered/est012.
Published 4
Ciampolini, R., Cecchi, F., Spaterna, A., Bramante, A., Bardet, S.M., Oulmouden, A. : Characterization of different 5'-untranslated exons of the ASIP gene in black-and-tan Doberman Pinscher and brindle Boxer dogs. Anim Genet 44:114-7, 2013. Pubmed reference: 22524303. DOI: 10.1111/j.1365-2052.2012.02364.x.
Body/System/Process
Coat Colour/Pattern/Type
OMIA Url
Inheritance
AR
HSP Test-Specific Data
Agrotis S.r.l.
GTP
GTP Name
Agrotis S.r.l.
Breed
OMIA
Gene Name
ASIP
Mutation
c.244G>T; p.A82S; c.248G>A; p.R83H; c.286C>T; p.R96C
BioBank AS
GTP
GTP Name
BioBank AS
Breed
OMIA
Gene Name
ASIP
Mutation
c.244G>T; p.A82S; c.248G>A; p.R83H; c.286C>T; p.R96C
Generatio GmbH Center for Animal Genetics
GTP
GTP Name
Generatio GmbH Center for Animal Genetics
Breed
OMIA
GTP Disease Name
A Locus (Agouti)
Gene Name
ASIP
Mutation
p.R96C
Certagen GmbH
GTP
GTP Name
Certagen GmbH
Breed
OMIA
Gene Name
ASIP
Mutation
c.244G>T; p.A82S; c.248G>A; p.R83H; c.286C>T; p.R96C
CMSCH
GTP
GTP Name
CMSCH
Breed
OMIA
Gene Name
ASIP
Mutation
c.244G>T; p.A82S; c.248G>A; p.R83H; c.286C>T; p.R96C
DNA My Dog
GTP
GTP Name
DNA My Dog
Breed
OMIA
GTP Disease Name
A Locus (Agouti)
Gene Name
ASIP
Mutation
c.244G>T; p.A82S; c.248G>A; p.R83H; c.286C>T; p.R96C
Nature of test
mutation test
This test is outsourced to:
Orivet
FCI Number
-20
GTP Breed
ALL
EVG Diagnostics
GTP
GTP Name
EVG Molecular Diagnostics
Breed
OMIA
Gene Name
ASIP
Mutation
c.244G>T; p.A82S; c.248G>A; p.R83H; c.286C>T; p.R96C
Genomia s.r.o
GTP
GTP Name
Genomia s.r.o
Breed
OMIA
GTP Disease Name
A Locus (Agouti)
GTP Disease Synonym
Agouti
Gene Name
ASIP
Mutation
c.244G>T; p.A82S; c.248G>A; p.R83H; c.286C>T; p.R96C
Mutation Comment
g.23393552C>T
Nature of test
mutation test
FCI Number
-20
GTP Breed
ALL
GenSol Diagnostics
GTP
GTP Name
GenSol Diagnostics
Breed
OMIA
GTP Disease Name
A Locus (Agouti)
Gene Name
ASIP
Mutation
p.R96C
GTP- or Breed-Specific Publications
Kerns JA, J Newton, TG Berryere, EM Rubin, JF Cheng, SM Schmutz and GS Barsch. Characterization of the dog Agouti gene and a nonagouti mutation in German Shepard Dogs. Mammalian Genome 15:798-808 (2004).
INNO
GTP
GTP Name
INNO
Breed
OMIA
Gene Name
ASIP
Mutation
c.244G>T; p.A82S; c.248G>A; p.R83H; c.286C>T; p.R96C
Laboratorios Labocor S.L.
GTP
GTP Name
Laboratorios Labocor S.L.
Breed
OMIA
Gene Name
ASIP
Mutation
c.244G>T; p.A82S; c.248G>A; p.R83H; c.286C>T; p.R96C
Laboklin Gmbh & Co. KG
GTP
GTP Name
Laboklin Gmbh & Co. KG
Breed
OMIA
GTP Disease Name
A Locus (Agouti)
Gene Name
ASIP
Mutation
c.244G>T; p.A82S; c.248G>A; p.R83H; c.286C>T; p.R96C
Nature of test
mutation test
FCI Number
-20
Orivet Genetic Pet Care
GTP
GTP Name
Orivet Genetic Pet Care
Breed
OMIA
GTP Disease Name
A Locus (Agouti)
Gene Name
ASIP
Mutation
c.244G>T; p.A82S; c.248G>A; p.R83H; c.286C>T; p.R96C
Nature of test
mutation test
FCI Number
-20
GTP Breed
ALL
Paw Print Genetics
GTP
GTP Name
Paw Print Genetics
Breed
OMIA
GTP Disease Name
A Locus (Agouti)
Gene Name
ASIP
Mutation
c.244G>T; p.A82S; c.248G>A; p.R83H; c.286C>T; p.R96C
Nature of test
mutation test
FCI Number
-20
PharmaDNA
GTP
GTP Name
PharmaDNA
Breed
OMIA
Gene Name
ASIP
Mutation
c.244G>T; p.A82S; c.248G>A; p.R83H; c.286C>T; p.R96C
Independent Veterinary Laboratory POISK
GTP
GTP Name
Independent Veterinary Laboratory POISK
Breed
OMIA
GTP Disease Name
A Locus (Agouti)
Gene Name
ASIP
Mutation
c.244G>T; p.A82S; c.248G>A; p.R83H; c.286C>T; p.R96C
Progènes-ADN
GTP
GTP Name
Progenes ADN
Breed
OMIA
Gene Name
ASIP
Mutation
c.244G>T; p.A82S; c.248G>A; p.R83H; c.286C>T; p.R96C
Veterinary Genetics Laboratory
GTP
GTP Name
Veterinary Genetics Laboratory
Breed
OMIA
GTP Disease Name
A Locus (Agouti)
Gene Name
ASIP
Mutation
c.244G>T; p.A82S; c.248G>A; p.R83H; c.286C>T; p.R96C
Nature of test
mutation test
GTP- or Breed-Specific Publications
Kerns JA, J Newton, TG Berryere, EM Rubin, JF Cheng, SM Schmutz and GS Barsch. Characterization of the dog Agouti gene and a nonagouti mutation in German Shepard Dogs. Mammalian Genome 15:798-808 (2004).
FCI Number
-20
GTP Breed
ALL
VHL Genetics
GTP
GTP Name
VHL Genetics
Breed
OMIA
Gene Name
ASIP
Mutation
c.244G>T; p.A82S; c.248G>A; p.R83H; c.286C>T; p.R96C
Wisdom Panel - Kinship
GTP
GTP Name
Wisdom Panel - Kinship
Breed
OMIA
GTP Disease Name
A Locus (Agouti)
Gene Name
ASIP
Mutation
c.244G>T; p.A82S; c.248G>A; p.R83H; c.286C>T; p.R96C
Nature of test
mutation test
FCI Number
-20
GTP Breed
ALL
Zoolyx
GTP
GTP Name
Zoolyx
Breed
OMIA
Gene Name
ASIP
Mutation
c.244G>T; p.A82S; c.248G>A; p.R83H; c.286C>T; p.R96C
AnimaLabs
GTP
GTP Name
AnimaLabs
Breed
OMIA
-
HGTD Quick Search
-
The portal for Genetic Testing Providers (labs); genetic tests, and tests by breed: as well as information on quality indicators and genetic counseling resources.
GOAL: Robust genetic testing supporting health improvements & a sustainable future for healthy dogs. -
HGTD Database Resources
How to use the HGTD
Using HGTD - YouTube Videos
HGTD Quality Indicators
Acronyms - Mode of Inheritance♦ 2020-New What is a Relevance Rating?
FAQs
Answers to frequently asked questions about the HGTD
Accreditation Basics
This brief overview may help you identify what types of accreditation are important to you, when choosing your genetic test provider.
Accreditation and Industry Standards
List of organizations throughout the world that are involved in matters of accreditation and establishing industry standards.
Choosing a Genetic Test Provider
Choosing a genetic test provider can be daunting. This short article helps you to consider what is important to you, and your dogs, in finding the right test provider for you. -
The HGTD's genetic counselling resources index provides access to basic introductory articles on genetics, articles on application of genetics in breed health management, and advanced work in technical genetics research. Breed-specific information is also available in our Pedigreed Dogs Database.
