Jump to content
International Collaboration For Dog Health And Welfare. Join Us.

Canine Cyclic Neutropenia (Grey Collie Syndrome)

Breed: Collie Smooth

Generic Phene Data

General

Disease Name
Canine Cyclic Neutropenia (Grey Collie Syndrome)
Disease Name 2
Cyclic Hematopoiesis
OMIA
248
Gene Name
AP3B1
Mutation
c.2401_2402insA
OMIM
608233
Disease Code
CCN
Test Type
Genetic Disease/Disorder
Details
Cyclic Neutropenia (CN) is also known as Cyclic Hematopoiesis or "Gray Collie Syndrome." CN affects the neutrophils of a dog, which are an integral part of the dog's immune system. In a cycle of 10-12 days, the dog will experience a dramatic drop in the number of neutrophils circulating through the blood stream, leaving them extremely susceptible to infections. This can manifest as diarrhoea, fever, joint pain or eye, respiratory, or skin infections. Bleeding episodes can also occur. Puppies who are affected will appear visibly lighter in colour than non-affected littermates. This also applies to merle pups. Age of onset from birth/puppyhood, and sadly most affected dogs will die as puppies. Even with optimum care, dogs don't live beyond 2-3 years of age.
Details 2
Cyclic Neutropenia (CN) is also known as Cyclic Hematopoiesis or "Gray Collie Syndrome." CN affects the neutrophils of a dog, which are an integral part of the dog's immune system. In a cycle of 10-12 days, the dog will experience a dramatic drop in the number of neutrophils circulating through the blood stream, leaving them extremely susceptible to infections. This can manifest as diarrhoea, fever, joint pain or eye, respiratory, or skin infections. Bleeding episodes can also occur. Puppies who are affected will appear visibly lighter in colour than non-affected littermates. This also applies to merle pups. Age of onset from birth/puppyhood, and sadly most affected dogs will die as puppies. Even with optimum care, dogs don't live beyond 2-3 years of age.
Published
Meng, R., Bridgman, R., Toivio-Kinnucan, M., Niemeyer, GP., Vernau, W., Hock, T., Lothrop, CD. : Neutrophil elastase-processing defect in cyclic hematopoietic dogs. Exp Hematol 38:104-15, 2010. Pubmed reference: 19941936. DOI: 10.1016/j.exphem.2009.09.010.
Body/System/Process
Blood
Inheritance
AR
Gene Name Text
AP-3 complex subunit beta-1

Breed Specific Data

CAG GmbH Center for Animal Genetics

Link to GTP
GTP Disease Name
Gray collie syndrome, cyclic neutropenia
GTP Disease Synonym
Canine Cyclic Neutropenia (Grey Collie Syndrome)
Gene Name
AP3B1
Mutation
c.2401_2402insA
Nature of test
mutation test
GTP- or Breed-Specific Publications
Meng, R., Bridgman, R., Toivio-Kinnucan, M., Niemeyer, GP., Vernau, W., Hock, T., Lothrop, CD. : Neutrophil elastase-processing defect in cyclic hematopoietic dogs. Exp Hematol 38:104-15, 2010. Pub
Application in the Breed
Carriers may be bred to normal animals (N/ccn x N/N) . Offspring should be tested before breeding. No breeding of two carriers (N/ccn x N/ccn) nor of affected animals (ccn/ccn). Two-week cyclical fluctuations in white blood cell levels, associated with fevers and potentially fatal infections
Inheritance
AR

Laboklin Gmbh & Co. KG

Link to GTP
GTP Disease Name
Gray collie syndrome, cyclic neutropenia
Gene Name
AP3B1
Mutation
c.2401_2402insA
Nature of test
mutation test

Paw Print Genetics

Link to GTP
GTP Disease Name
Gray collie syndrome, cyclic neutropenia
Gene Name
AP3B1
Mutation
c.2401_2402insA
Nature of test
mutation test

EVG Diagnostics

Link to GTP
Gene Name
AP3B1
Mutation
c.2401_2402insA
Nature of test
mutation test
GTP- or Breed-Specific Publications
Nature Genetics 35, 90 - 96 (2003)

VetGen LLC

Link to GTP
Gene Name
AP3B1
Mutation
c.2401_2402insA

GenSol Diagnostics

Link to GTP
GTP Disease Name
Gray collie syndrome, cyclic neutropenia
Gene Name
AP3B1
Mutation
c.2401_2402insA
GTP- or Breed-Specific Publications
Meng, R., Bridgman, R., Toivio-Kinnucan, M., Niemeyer, GP., Vernau, W., Hock, T., Lothrop, CD. : Neutrophil elastase-processing defect in cyclic hematopoietic dogs. Exp Hematol 38:104-15, 2010. Pub
Application in the Breed
Carriers may be bred to normal animals (N/ccn x N/N) . Offspring should be tested before breeding. No breeding of two carriers (N/ccn x N/ccn) nor of affected animals (ccn/ccn). Two-week cyclical fluctuations in white blood cell levels, associated with fevers and potentially fatal infections

GenSol Diagnostics

Link to GTP
GTP Disease Name
Gray collie syndrome, cyclic neutropenia
Gene Name
AP3B1
Mutation
c.2401_2402insA
GTP- or Breed-Specific Publications
Meng, R., Bridgman, R., Toivio-Kinnucan, M., Niemeyer, GP., Vernau, W., Hock, T., Lothrop, CD. : Neutrophil elastase-processing defect in cyclic hematopoietic dogs. Exp Hematol 38:104-15, 2010. Pub
Application in the Breed
Carriers may be bred to normal animals (N/ccn x N/N) . Offspring should be tested before breeding. No breeding of two carriers (N/ccn x N/ccn) nor of affected animals (ccn/ccn). Two-week cyclical fluctuations in white blood cell levels, associated with fevers and potentially fatal infections
×
×
  • Create New...

Important Information

By using this site, you agree to our Terms of Use.