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Factor VII Deficiency
Breed: Continental Toy Spaniel Phalène/ with hanging ears
Generic Phene Data
Breeds
Relevance Rating: There is some evidence or research available for these breeds
Relevance Rating: The test is unknown, there is no evidence (i.e. research) available, or it has not been evaluated yet. These tests may or may not be meaningful for these breeds
General
Disease Name
Factor VII Deficiency
OMIA
361
Gene Name
FVII
Mutation
c.407G>A
Mutation 2
c.6385G>A
Test Type
Genetic Disease/Disorder
Details
Blood coagulation problems noted in pregnant/ postpartum females. Some animals prolonged bleeding from injuries/surgeries.
Published
Callan MB, Aljamali MN, Margaritis P, Griot-Wenk ME, Pollak ES, Werner P, Giger U, High KA. A novel missense mutation responsible for factor VII deficiency in research Beagle colonies. J Thromb Haemost 2006; 4: 2616?22.
Published 2
Carlstrom, LP., Jens, JK., Dobyns, ME., Passage, M., Dickson, PI., Ellinwood, NM. : Inadvertent propagation of factor VII deficiency in a canine mucopolysaccharidosis type I research breeding colony. Comp Med 59:378-82, 2009. Pubmed reference: 19712579.
Body/System/Process
Blood
OMIA Url
Inheritance
AR
HSP Test-Specific Data
Zoolyx
GTP
GTP Name
Zoolyx
Breed
OMIA
Gene Name
FVII
Mutation
c.407G>A; c.6385G>A
VHL Genetics
GTP
GTP Name
VHL Genetics
Breed
OMIA
Gene Name
FVII
Mutation
c.407G>A; c.6385G>A
Veterinary Genetics Laboratory
GTP
GTP Name
Veterinary Genetics Laboratory
Breed
OMIA
GTP Disease Name
proconvertin deficiency, FVII
GTP Disease Synonym
proconvertin deficiency, FVII
Gene Name
FVII
Mutation
c.407G>A
Nature of test
mutation test
GTP- or Breed-Specific Publications
Callan MB, Aljamali MN, Margaritis P, Griot-Wenk ME, Pollak ES, Werner P, Giger U and High KA (2006). A novel missense mutation responsible for factor VII deficiency in research Beagle colonies. Journal of Thrombosis and Haemostasis, 4:2616?2622.
Application in the Breed
Carriers can be bred to normal animals (N/fIX x N/N) .Offspring should be tested before breeding. No breeding of two carriers (N/fIX x N/fIX). Blood coagulation problems noted in pregnant/ postpartum females. Some animals prolonged bleeding from injuries/surgeries.
Inheritance
AR
FCI Number
77
GTP Breed
Papillon/Phalene
Progènes-ADN
GTP
GTP Name
Progenes ADN
Breed
OMIA
Gene Name
FVII
Mutation
c.407G>A; c.6385G>A
PharmaDNA
GTP
GTP Name
PharmaDNA
Breed
OMIA
Gene Name
FVII
Mutation
c.407G>A; c.6385G>A
Paw Print Genetics
GTP
GTP Name
Paw Print Genetics
Breed
OMIA
GTP Disease Name
proconvertin deficiency, FVII
Gene Name
FVII
Mutation
c.407G>A
Nature of test
mutation test
FCI Number
77
Laboratorios Labocor S.L.
GTP
GTP Name
Laboratorios Labocor S.L.
Breed
OMIA
Gene Name
FVII
Mutation
c.407G>A; c.6385G>A
INNO
GTP
GTP Name
INNO
Breed
OMIA
Gene Name
FVII
Mutation
c.407G>A; c.6385G>A
GenSol Diagnostics
GTP
GTP Name
GenSol Diagnostics
Breed
OMIA
GTP Disease Name
proconvertin deficiency, FVII
Gene Name
FVII
Mutation
c.6385G>A
Genomia s.r.o
GTP
GTP Name
Genomia s.r.o
Breed
OMIA
GTP Disease Name
proconvertin deficiency, FVII
Gene Name
FVII
Mutation
c.407G>A
Mutation Comment
g.60578895G>A
Nature of test
mutation test
EVG Diagnostics
GTP
GTP Name
EVG Molecular Diagnostics
Breed
OMIA
Gene Name
FVII
Mutation
c.407G>A
CMSCH
GTP
GTP Name
CMSCH
Breed
OMIA
Gene Name
FVII
Mutation
c.407G>A; c.6385G>A
Certagen GmbH
GTP
GTP Name
Certagen GmbH
Breed
OMIA
Gene Name
FVII
Mutation
c.407G>A; c.6385G>A
BioBank AS
GTP
GTP Name
BioBank AS
Breed
OMIA
Gene Name
FVII
Mutation
c.407G>A; c.6385G>A
Agrotis S.r.l.
GTP
GTP Name
Agrotis S.r.l.
Breed
OMIA
Gene Name
FVII
Mutation
c.407G>A; c.6385G>A
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