DonateFactor VII Deficiency
Breed: Continental Toy Spaniel Phalène/ with hanging ears
Generic Phene Data
Breeds
Relevance Rating: There is some evidence or research available for these breeds
Relevance Rating: The test is unknown, there is no evidence (i.e. research) available, or it has not been evaluated yet. These tests may or may not be meaningful for these breeds
General
Disease Name
Factor VII Deficiency
OMIA
361
Gene Name
FVII
Mutation
c.407G>A
Mutation 2
c.6385G>A
Details
Blood coagulation problems noted in pregnant/ postpartum females. Some animals prolonged bleeding from injuries/surgeries.
Published
Callan MB, Aljamali MN, Margaritis P, Griot-Wenk ME, Pollak ES, Werner P, Giger U, High KA. A novel missense mutation responsible for factor VII deficiency in research Beagle colonies. J Thromb Haemost 2006; 4: 2616?22.
Published 2
Carlstrom, LP., Jens, JK., Dobyns, ME., Passage, M., Dickson, PI., Ellinwood, NM. : Inadvertent propagation of factor VII deficiency in a canine mucopolysaccharidosis type I research breeding colony. Comp Med 59:378-82, 2009. Pubmed reference: 19712579.
Body/System/Process
Blood
OMIA Url
Inheritance
AR
GTP Test-Specific Data
Agrotis S.r.l.
GTP
GTP Name
Agrotis S.r.l.
Gene Name
FVII
Mutation
c.407G>A; c.6385G>A
BioBank AS
GTP
GTP Name
BioBank AS
Gene Name
FVII
Mutation
c.407G>A; c.6385G>A
Certagen GmbH
GTP
GTP Name
Certagen GmbH
Gene Name
FVII
Mutation
c.407G>A; c.6385G>A
CMSCH
GTP
GTP Name
CMSCH
Gene Name
FVII
Mutation
c.407G>A; c.6385G>A
EVG Diagnostics
GTP
GTP Name
EVG Molecular Diagnostics
Gene Name
FVII
Mutation
c.407G>A
Genomia s.r.o
GTP
GTP Name
Genomia s.r.o
GTP Disease Name
proconvertin deficiency, FVII
Gene Name
FVII
Mutation
c.6385G>A
Nature of test
mutation test
GenSol Diagnostics
GTP Name
GenSol Diagnostics
GTP Disease Name
proconvertin deficiency, FVII
Gene Name
FVII
Mutation
c.6385G>A
INNO
GTP
GTP Name
INNO
Gene Name
FVII
Mutation
c.407G>A; c.6385G>A
Laboratorios Labocor S.L.
GTP Name
Laboratorios Labocor S.L.
Gene Name
FVII
Mutation
c.407G>A; c.6385G>A
Paw Print Genetics
GTP Name
Paw Print Genetics
GTP Disease Name
proconvertin deficiency, FVII
Gene Name
FVII
Mutation
c.407G>A
Nature of test
mutation test
FCI Number
77
PharmaDNA
GTP
GTP Name
PharmaDNA
Gene Name
FVII
Mutation
c.407G>A; c.6385G>A
Progènes-ADN
GTP
GTP Name
Progenes ADN
Gene Name
FVII
Mutation
c.407G>A; c.6385G>A
Veterinary Genetics Laboratory
GTP Name
Veterinary Genetics Laboratory
GTP Disease Name
proconvertin deficiency, FVII
GTP Disease Synonym
proconvertin deficiency, FVII
Gene Name
FVII
Mutation
c.407G>A
Nature of test
mutation test
GTP- or Breed-Specific Publications
Callan MB, Aljamali MN, Margaritis P, Griot-Wenk ME, Pollak ES, Werner P, Giger U and High KA (2006). A novel missense mutation responsible for factor VII deficiency in research Beagle colonies. Journal of Thrombosis and Haemostasis, 4:2616?2622.
Application in the Breed
Carriers can be bred to normal animals (N/fIX x N/N) .Offspring should be tested before breeding. No breeding of two carriers (N/fIX x N/fIX). Blood coagulation problems noted in pregnant/ postpartum females. Some animals prolonged bleeding from injuries/surgeries.
Inheritance
AR
FCI Number
77
GTP Breed
Papillon/Phalene
VHL Genetics
GTP
GTP Name
VHL Genetics
Gene Name
FVII
Mutation
c.407G>A; c.6385G>A
Zoolyx
GTP
GTP Name
Zoolyx
Gene Name
FVII
Mutation
c.407G>A; c.6385G>A
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