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Furnishings (moustache and eyebrows)

Breed: Chinese Crested Dogs

Generic Phene Data

Breeds
Relevance Rating: The test is unknown, there is no evidence (i.e. research) available, or it has not been evaluated yet. These tests may or may not be meaningful for these breeds
GTPs
Genomia s.r.o

General

Disease Name
Furnishings (moustache and eyebrows)
OMIA
1531
Gene Name
RSPO2
Mutation
167 bp insertion in 3'UTR region
Mutation Notes
Insertion is within the 3'UTR at position 11,634,766, which leads to a threefold increase in transcription of RSPO2
Test Type
Other Genetic Traits
Details
Furnishings refers to the longer moustache and eyebrows seen in dogs with wire-hair and can also be seen in other breeds. Furnishings are a dominant trait, meaning that a dog only needs to have one copy of the furnishings gene to show that physical trait. Dogs that are heterozygous for the furnishings gene can pass on either the furnishings gene, or the non-furnishings gene to any offspring.
Details 2
Furnishings refers to the longer moustache and eyebrows seen in dogs with wire-hair and can also be seen in other breeds. Furnishings are a dominant trait, meaning that a dog only needs to have one copy of the furnishings gene to show that physical trait. Dogs that are heterozygous for the furnishings gene can pass on either the furnishings gene, or the non-furnishings gene to any offspring.
Published
Cadieu, E., Neff, M.W., Quignon, P., Walsh, K., Chase, K., Parker, H.G., Vonholdt, B.M., Rhue, A., Boyko, A., Byers, A., Wong, A., Mosher, D.S., Elkahloun, A.G., Spady, T.C., André, C., Lark, K.G., Cargill, M., Bustamante, C.D., Wayne, R.K., Ostrander, E.A. : Coat variation in the domestic dog is governed by variants in three genes. Science 326:150-3, 2009. Pubmed reference: 19713490. DOI: 10.1126/science.1177808.
Published 2
Vaysse, A., Ratnakumar, A., Derrien, T., Axelsson, E., Rosengren Pielberg, G., Sigurdsson, S., Fall, T., Seppälä, E.H., Hansen, M.S., Lawley, C.T., Karlsson, E.K. : Identification of genomic regions associated with phenotypic variation between dog breeds using selection mapping. PLoS Genet 7:e1002316, 2011. Pubmed reference: 22022279. DOI: 10.1371/journal.pgen.1002316.
Published 3
Parker, H.G., Harris, A., Dreger, D.L., Davis, B.W., Ostrander, E.A. : The bald and the beautiful: hairlessness in domestic dog breeds. Philos Trans R Soc Lond B Biol Sci 372:, 2017. Pubmed reference: 27994129. DOI: 10.1098/rstb.2015.0488.
Body/System/Process
Coat Colour/Pattern/Type
Inheritance
A

Breed Specific Info

Breed-specific 1
Shorthaired Hungarian Vizslas
Breed-specific 1 Details
It is generally considered that furnishings are not part of the Shorthaired Hungarian Vizslas genetic makeup.

Key Comment

furnishings have the potential relevance to any dog, but test usage is most often applied to those breeds with a heritage of these traits.

HSP Test-Specific Data

Genomia s.r.o

GTP
GTP Name
Genomia s.r.o
Breed
OMIA
GTP Disease Name
IC Locus (Improper Coat/Furnishings)
GTP Disease Synonym
Furnishings
Gene Name
RSPO2
Mutation
167 bp insertion in 3'UTR region
Nature of test
mutation test
FCI Number
288
GTP Breed
Chinese crested dogs
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