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Polyneuropathy - NDRG1 Type (AMPN)


Relevance Rating: Some evidence for test being meaningful for these breeds

Relevance Rating: Unknown, not evaluated or no evidence for test for these breeds


Disease Name
Polyneuropathy - NDRG1 Type (AMPN)
Mutation 2
Test Type
Genetic Disease/Disorder
Polyneuropathy describes many abnormalities of the nervous system including sensory nerves, motor nerves, and autonomic nerves. Signs include progressive weakness, exercise intolerance, high-steppage, change in bark pitch and difficulty breathing. Age of onset 7 to 20 months of age. Symptoms can be progressive.
Drogemuller, C., Becker, D., Kessler, B., Kemter, E., Tetens, J., Jurina, K., Jaderlund, KH., Flagstad, A., Perloski, M., Lindblad-Toh, K., Matiasek, K. : A deletion in the N-myc downstream regulated gene 1 (NDRG1) gene in Greyhounds with polyneuropathy. PLoS One 5:e11258, 2010. Pubmed reference: 20582309. DOI: 10.1371/journal.pone.0011258.
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