Reminder: Login to access new features and members-only content!

Register to be a member of our community. Its easy!

Register a new account

Already a member?

Log In here!

Donate

Did you find our content interesting or helpful? Help support the IPFD enhance health, well-being and welfare for dogs everywhere.

Jump to content
  •   Language
  • Sign Up

International Partnership for Dogs - Enhancing Dog Health, Well-Being, and Welfare - Join Us.

Early Retinal Degeneration (ERD)

Breeds

Relevance Rating: Unknown, not evaluated or no evidence for test for these breeds

General

Disease Name
Early Retinal Degeneration (ERD)
Mutation
c.186ins229bp,15bp dup
Test Type
Genetic Disease/Disorder
Details
ERD is an early onset hereditary retinal degeneration characterized by retina cells being lost, leading first to problems seeing in dim light. Affected dogs are initially nightblind, but may become totally blind between 12- and 18 months of age.
Details 2
Affected dogs are initially nightblind, and become totally blind between 12- and 18 months of age. The postnatal development of their rod and cone photoreceptors is abnormal both structurally and functionally. Morphologically, rod and cone inner- and outer-segment growth occurs but appears uncoordinated. Adjacent rods become very disparate in the size and proportions of their inner- and outer segments. Subsequent to these abnormalities of development, the rods and cones degenerate, rapidly at first and later more gradually. (from Ackland 1987)
Published
Goldstein, O., Kukekova, AV., Aguirre, GD., Acland, GM. : Exonic SINE insertion in STK38L causes canine early retinal degeneration (erd). Genomics :, 2010. Pubmed reference: 20887780. DOI: 10.1016/j.ygeno.2010.09.003.
×
×
  • Create New...

Important Information

By using this site, you agree to our Terms of Use.