ERD is an early onset hereditary retinal degeneration characterized by retina cells being lost, leading first to problems seeing in dim light. Affected dogs are initially nightblind, but may become totally blind between 12- and 18 months of age.
Affected dogs are initially nightblind, and become totally blind between 12- and 18 months of age. The postnatal development of their rod and cone photoreceptors is abnormal both structurally and functionally. Morphologically, rod and cone inner- and outer-segment growth occurs but appears uncoordinated. Adjacent rods become very disparate in the size and proportions of their inner- and outer segments. Subsequent to these abnormalities of development, the rods and cones degenerate, rapidly at first and later more gradually. (from Ackland 1987)
Goldstein, O., Kukekova, AV., Aguirre, GD., Acland, GM. : Exonic SINE insertion in STK38L causes canine early retinal degeneration (erd). Genomics :, 2010. Pubmed reference: 20887780. DOI: 10.1016/j.ygeno.2010.09.003.
Choosing a Genetic Test Provider Choosing a genetic test provider can be daunting. This short article helps you to consider what is important to you, and your dogs, in finding the right test provider for you.
The HGTD genetic counselling resources index link above and links below provide access to basic introductory articles on genetics, articles on application of genetics in breed health management and advanced work in technical genetics research. Breed-specific information is also available in DWN's Pedigreed Dogs Database.