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Protein Losing Nephropathy

Breeds

Relevance Rating: The test is unknown, there is no evidence (i.e. research) available, or it has not been evaluated yet. These tests may or may not be meaningful for these breeds

General

Disease Name
Protein Losing Nephropathy
Gene Name 2
KIRREL2
Mutation
N1:c.3067G>A
Mutation 2
K2:c.1877C>G
Test Type
Genetic Disease/Disorder
Details
Protein Losing Nephropathy is a disease of the kidneys which can lead to stones, bloody urine, or loss of blood components. Protein-losing nephropathy is a specific kind of kidney ailment that usually affects large-breed dogs, characterised by protein and blood serum entering the urine, often leading to fatal end-stage kidney failure if not caught and treated promptly.
Details 2
Protein Losing Nephropathy is a disease of the kidneys which can lead to stones, bloody urine, or loss of blood components. Protein-losing nephropathy is a specific kind of kidney ailment that usually affects large-breed dogs, characterised by protein and blood serum entering the urine, often leading to fatal end-stage kidney failure if not caught and treated promptly.
Published
Littman, M.P., Wiley, C.A., Raducha, M.G., Henthorn, P.S. : Glomerulopathy and mutations in NPHS1 and KIRREL2 in soft-coated Wheaten Terrier dogs. Mamm Genome 24:119-26, 2013. Pubmed reference: 23325127. DOI: 10.1007/s00335-012-9445-8.

Breed Specific Info

Researched Breeds
Soft Coated Wheaten Terrier
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