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Protein Losing Nephropathy

Breeds

Relevance Rating: Unknown, not evaluated or no evidence for test for these breeds

General

Disease Name
Protein Losing Nephropathy
Gene Name 2
KIRREL2
Mutation
N1:c.3067G>A
Mutation 2
K2:c.1877C>G
Test Type
Genetic Disease/Disorder
Details
Protein Losing Nephropathy is a disease of the kidneys which can lead to stones, bloody urine, or loss of blood components. Protein-losing nephropathy is a specific kind of kidney ailment that usually affects large-breed dogs, characterised by protein and blood serum entering the urine, often leading to fatal end-stage kidney failure if not caught and treated promptly.
Details 2
Protein Losing Nephropathy is a disease of the kidneys which can lead to stones, bloody urine, or loss of blood components. Protein-losing nephropathy is a specific kind of kidney ailment that usually affects large-breed dogs, characterised by protein and blood serum entering the urine, often leading to fatal end-stage kidney failure if not caught and treated promptly.
Published
Littman, M.P., Wiley, C.A., Raducha, M.G., Henthorn, P.S. : Glomerulopathy and mutations in NPHS1 and KIRREL2 in soft-coated Wheaten Terrier dogs. Mamm Genome 24:119-26, 2013. Pubmed reference: 23325127. DOI: 10.1007/s00335-012-9445-8.
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