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Progressive Retinal Atrophy Autosomal Dominant (ADPRA)


Relevance Rating: The test is unknown, there is no evidence (i.e. research) available, or it has not been evaluated yet. These tests may or may not be meaningful for these breeds


Disease Name
Progressive Retinal Atrophy Autosomal Dominant (ADPRA)
Mutation 2
Test Type
Genetic Disease/Disorder
As detailed by Kijas et al. (2002), vision is normal for the first few months, but by 12-18 months, vision loss is spreading slowly with particular problems for the dog moving between different light levels. Homozygotes (two copies of the abnormal gene) have more severe clinical signs than heterozygotes (one copy of the abnormal gene).
Details 2
From Kijas et al. (2002), rod vision is normal for at least the first few months. But by 12-18 months, degeneration is evident, spreading slowly from a disease focus in one retinal region. In addition, there is an abnormally slow recovery of rod photoreceptor function after exposure to light. Homozygotes have more severe clinical signs than heterozygotes.
Kijas, JW., Miller, BJ., Pearce-Kelling, SE., Aguirre, GD., Acland, GM.: Canine models of ocular disease: outcross breedings define a dominant disorder present in the English mastiff and bull mastiff dog breeds. J Hered 94:27-30, 2003. Pubmed reference: 12692159.
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