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Neuropathy, Sensory Ataxic


Relevance Rating: There is some evidence or research available in this breed

Relevance Rating: The test is unknown, there is no evidence (i.e. research) available, or it has not been evaluated yet. These tests may or may not be meaningful in this breed


Disease Name
Neuropathy, Sensory Ataxic
Test Type
Genetic Disease/Disorder
Sensory ataxic neuropathy (SAN) is a slowly progressive neurological disorder causing degeneration in the central and peripheral nervous system. Signs include: ataxia, postural reaction deficits, reduced or absent spinal reflexes. Age of onset from puppyhood. Around half of dogs are euthanized before three years of age, if badly affected.
Details 2
Sensory ataxic neuropathy (SAN) is a recently identified neurological disorder in golden retrievers...The mutation could be traced back to a common ancestor of all affected dogs that lived in the 1970s...SAN has an insidious onset during puppyhood, followed by slow progression. Males and females are affected at similar frequencies. Affected dogs are ataxic, have postural reaction deficits and reduced or absent spinal reflexes. They have no pronounced muscle atrophy, and the dogs do not seem to be in pain. Electrophysiological examination revealed that they have reduced conduction velocities of nerve impulses in sensory nerves. Pathological examination indicated degenerative changes both in the central and peripheral nervous system. Approximately fifty percent of the affected dogs were euthanized before three years of age...(From Baranowska et al, 2009)
Baranowska, I., Jäderlund, K.H., Nennesmo, I., Holmqvist, E., Heidrich, N., Larsson, N.G., Andersson, G., Wagner, E.G., Hedhammar, A., Wibom, R., Andersson, L. : Sensory ataxic neuropathy in golden retriever dogs is caused by a deletion in the mitochondrial tRNATyr gene. PLoS Genet 5:e1000499, 2009. Pubmed reference: 19492087. DOI: 10.1371/journal.pgen.1000499.
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