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Nasal Parakeratosis
Breed: Labrador Retriever
Generic Phene Data
Breeds
Relevance Rating: There is some evidence or research available for these breeds
Relevance Rating: The test is unknown, there is no evidence (i.e. research) available, or it has not been evaluated yet. These tests may or may not be meaningful in this breed
GTPs
General
Disease Name
Nasal Parakeratosis
OMIA
1373
Gene Name
SUV39H2
Mutation
c.972T>G
Test Type
Genetic Disease/Disorder
Details
Hereditary nasal parakeratosis (HNPK) causes the nose to dry out leading to chronic irritation and inflammation of the nasal skin. Dogs develop dry, gray to brown crusts on the surface and edge of the nose, painful cracking and a tendency for infection. Skin color can change from dark to light over time. Age of onset average 6 to 12 months. Although not life-threatening, continuous care is required to manage nasal crusting for the dog's life.
Details 2
Hereditary nasal parakeratosis (HNPK), an inherited monogenic autosomal recessive skin disorder, leads to crusts and fissures on the nasal planum of Labrador Retrievers... (From Jagannath et al, 2013) Hereditary nasal dermatitis is reported in 14 Labrador Retrievers and 4 Labrador Retriever crosses...The lesions were first noted between 6 and 12 months of age. Histopathological analysis revealed parakeratotic hyperkeratosis, often with marked multifocal accumulation of proteinaceous fluid between keratinocytes within the stratum corneum and superficial stratum spinosum. There was also a sub-basal lymphoplasmacytic infiltration within the superficial dermis...(From Page et al, 2003)
Published
Jagannathan, V., Bannoehr, J., Plattet, P., Hauswirth, R., Drögemüller, C., Drögemüller, M., Wiener, D.J., Doherr, M., Owczarek-Lipska, M., Galichet, A., Welle, M.M., Tengvall, K., Bergvall, K., Lohi, H., Rüfenacht, S., Linek, M., Paradis, M., Müller, E.J., Roosje, P., Leeb, T. : A mutation in the SUV39H2 gene in Labrador Retrievers with hereditary nasal parakeratosis (HNPK) provides insights into the epigenetics of keratinocyte differentiation. PLoS Genet 9:e1003848, 2013. Pubmed reference: 24098150. DOI: 10.1371/journal.pgen.1003848.
Published 2
Bauer, A., Nimmo, J., Newman, R., Brunner, M., Welle, M.M., Jagannathan, V., Leeb, T. : A splice site variant in the SUV39H2 gene in Greyhounds with nasal parakeratosis. Anim Genet :, 2018. Pubmed reference: 29423952. DOI: 10.1111/age.12643.
Published 3
Page, N., Paradis, M., Lapointe, J.M., Dunstan, R.W. : Hereditary nasal parakeratosis in Labrador Retrievers Veterinary Dermatology 14:103-10, 2003. Pubmed reference: 12662268.
Body/System/Process
Skin
OMIA Url
Inheritance
AR
HSP Test-Specific Data
Laboratorios Labocor S.L.
GTP
GTP Name
Laboratorios Labocor S.L.
Breed
OMIA
Gene Name
SUV39H2
Mutation
c.972T>G
Laboklin Gmbh & Co. KG
GTP
GTP Name
Laboklin Gmbh & Co. KG
Breed
OMIA
GTP Disease Name
Dry Nose
Gene Name
SUV39H2
Mutation
c.972T>G
Nature of test
mutation test
GTP- or Breed-Specific Publications
Jagannathan, V., Bannoehr, J., Plattet, P., Hauswirth, R., Drógem?ller, C., Drógem?ller, M., Wiener, D.J., Doherr, M., Owczarek-Lipska, M., Galichet, A., Welle, M.M., Tengvall, K., Bergvall, K., Lohi,
Inheritance
AR
FCI Number
122
GTP Breed
Labrador Retriever
Certagen GmbH
GTP
GTP Name
Certagen GmbH
Breed
OMIA
Gene Name
SUV39H2
Mutation
c.972T>G
VHL Genetics
GTP
GTP Name
VHL Genetics
Breed
OMIA
Gene Name
SUV39H2
Mutation
c.972T>G
Zoolyx
GTP
GTP Name
Zoolyx
Breed
OMIA
Gene Name
SUV39H2
Mutation
c.972T>G
Weatherbys Scientific
GTP
GTP Name
Weatherbys Scientific
Breed
OMIA
GTP Disease Name
Dry Nose
Gene Name
SUV39H2
Mutation
c.972T>G
GenSol Diagnostics
GTP
GTP Name
GenSol Diagnostics
Breed
OMIA
GTP Disease Name
Dry Nose
Gene Name
SUV39H2
Mutation
c.972T>G
GTP- or Breed-Specific Publications
Jagannathan, V., Bannoehr, J., Plattet, P., Hauswirth, R., Drógem?ller, C., Drógem?ller, M., Wiener, D.J., Doherr, M., Owczarek-Lipska, M., Galichet, A., Welle, M.M., Tengvall, K., Bergvall, K., Lohi,
CMSCH
GTP
GTP Name
CMSCH
Breed
OMIA
Gene Name
SUV39H2
Mutation
c.972T>G
The Kennel Club
GTP
GTP Name
The Kennel Club
Breed
OMIA
GTP Disease Name
Dry Nose
Gene Name
SUV39H2
Mutation
c.972T>G
This test is outsourced to:
Weatherby's
Progènes-ADN
GTP
GTP Name
Progenes ADN
Breed
OMIA
Gene Name
SUV39H2
Mutation
c.972T>G
Orivet Genetic Pet Care
GTP
GTP Name
Orivet Genetic Pet Care
Breed
OMIA
GTP Disease Name
Dry Nose
Gene Name
SUV39H2
Mutation
c.972T>G
Nature of test
mutation test
GTP- or Breed-Specific Publications
Jagannathan, V., Bannoehr, J., Plattet, P., Hauswirth, R., Drógem?ller, C., Drógem?ller, M., Wiener, D.J., Doherr, M., Owczarek-Lipska, M., Galichet, A., Welle, M.M., Tengvall, K., Bergvall, K., Lohi,
Inheritance
AR
FCI Number
122
GTP Breed
Labrador Retriever
AnimaLabs
GTP
GTP Name
AnimaLabs
Breed
OMIA
PharmaDNA
GTP
GTP Name
PharmaDNA
Breed
OMIA
Gene Name
SUV39H2
Mutation
c.972T>G
INNO
GTP
GTP Name
INNO
Breed
OMIA
Gene Name
SUV39H2
Mutation
c.972T>G
Anicom Specialty Medical Institute Inc.
GTP
GTP Name
Anicom
Breed
OMIA
GTP Disease Name
Dry Nose
Gene Name
SUV39H2
Mutation
c.972T>G
VetGen LLC
GTP
GTP Name
VetGen LLC
Breed
OMIA
Gene Name
SUV39H2
Mutation
c.972T>G
Veterinary Genetics Laboratory
GTP
GTP Name
Veterinary Genetics Laboratory
Breed
OMIA
GTP Disease Name
Dry Nose
Gene Name
SUV39H2
Mutation
c.972T>G
Nature of test
mutation test
Paw Print Genetics
GTP
GTP Name
Paw Print Genetics
Breed
OMIA
GTP Disease Name
Dry Nose
Gene Name
SUV39H2
Mutation
c.972T>G
Nature of test
mutation test
FCI Number
122
Agrotis S.r.l.
GTP
GTP Name
Agrotis S.r.l.
Breed
OMIA
Gene Name
SUV39H2
Mutation
c.972T>G
EVG Diagnostics
GTP
GTP Name
EVG Molecular Diagnostics
Breed
OMIA
Gene Name
SUV39H2
Mutation
c.972T>G
BioBank AS
GTP
GTP Name
BioBank AS
Breed
OMIA
Gene Name
SUV39H2
Mutation
c.972T>G
Embark
GTP
GTP Name
Embark
Breed
OMIA
GTP Disease Name
Dry Nose
Gene Name
SUV39H2
Mutation
c.972T>G
Nature of test
mutation test
GTP- or Breed-Specific Publications
Jagannathan, V., Bannoehr, J., Plattet, P., Hauswirth, R., Drógem?ller, C., Drógem?ller, M., Wiener, D.J., Doherr, M., Owczarek-Lipska, M., Galichet, A., Welle, M.M., Tengvall, K., Bergvall, K., Lohi,
Inheritance
AR
FCI Number
122
GTP Breed
Labrador Retriever
DNA My Dog
GTP
GTP Name
DNA My Dog
Breed
OMIA
GTP Disease Name
Dry Nose
Gene Name
SUV39H2
Mutation
c.972T>G
Nature of test
mutation test
GTP- or Breed-Specific Publications
Jagannathan, V., Bannoehr, J., Plattet, P., Hauswirth, R., Drógem?ller, C., Drógem?ller, M., Wiener, D.J., Doherr, M., Owczarek-Lipska, M., Galichet, A., Welle, M.M., Tengvall, K., Bergvall, K., Lohi,
Inheritance
AR
This test is outsourced to:
Orivet
FCI Number
122
GTP Breed
Labrador Retriever
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