Neuronal Ceroid Lipofuscinosis 2 (NCL2)
Breed: Miniature Dachshund/ longhaired
Generic Phene Data
Breeds
Relevance Rating: There is some evidence or research available in this breed
Relevance Rating: The test is unknown, there is no evidence (i.e. research) available, or it has not been evaluated yet. These tests may or may not be meaningful for these breeds
General
Disease Name
Neuronal Ceroid Lipofuscinosis 2 (NCL2)
OMIA
1472
Gene Name
TPP1
Mutation
c.325delC
Test Type
Genetic Disease/Disorder
Details
The Neuronal ceroid lipofuscinosis (NCLs) are a group of inherited neurodegenerative diseases characterized by accumulation of autofluorescent cytoplasmic antibodies within cells of the nervous system. Affected dogs typically exhibit a condition of cerebellar dysfunction in which voluntary muscular movements tend to result in loss of control and coordination. Vision loss, difficulty see in dim light. Difficulty with balancing and walking, tremors, muscle twitching, seizures. Hyperactivity, aggression, and a decline cognitive abilities. Death by 12 months of age.
Details 2
The Neuronal ceroid lipofuscinosis (NCLs) are a group of inherited neurodegenerative diseases characterized by accumulation of autofluorescent cytoplasmic antibodies within cells of the nervous system. Affected dogs typically exhibit a condition of cerebellar dysfunction in which voluntary muscular movements tend to result in loss of control and coordination. Vision loss, difficulty see in dim light. Difficulty with balancing and walking, tremors, muscle twitching, seizures. Hyperactivity, aggression, and a decline cognitive abilities. Death by 12 months of age.
Published
Awano, T., Katz, ML., O'Brien, DP., Sohar, I., Lobel, P., Coates, JR., Khan, S., Johnson, GC., Giger, U., Johnson, GS. : A frame shift mutation in canine TPP1 (the ortholog of human CLN2) in a juvenile Dachshund with neuronal ceroid lipofuscinosis. Mol Genet Metab 89:254-60, 2006. Pubmed reference: 16621647. DOI: 10.1016/j.ymgme.2006.02.016.
Body/System/Process
Metabolic
OMIA Url
Inheritance
AR
HSP Test-Specific Data
Generatio GmbH Center for Animal Genetics
GTP
GTP Name
Generatio GmbH Center for Animal Genetics
Breed
OMIA
Gene Name
TPP1
Mutation
c.325delC
AnimaLabs
GTP
GTP Name
AnimaLabs
Breed
OMIA
VetGen LLC
GTP
GTP Name
VetGen LLC
Breed
OMIA
Gene Name
TPP1
Mutation
c.325delC
Key Comment