The Neuronal ceroid lipofuscinosis (NCLs) are a group of inherited neurodegenerative diseases characterized by accumulation of autofluorescent cytoplasmic antibodies within cells of the nervous system. Affected dogs typically exhibit a condition of cerebellar dysfunction in which voluntary muscular movements tend to result in loss of control and coordination. Vision loss, difficulty see in dim light. Difficulty with balancing and walking, tremors, muscle twitching, seizures. Hyperactivity, aggression, and a decline cognitive abilities. Death by 12 months of age.