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Conjunctivitis/ Ligneous Membranitis

Breeds

Relevance Rating: Unknown, not evaluated or no evidence for test for these breeds

General

Disease Name
Conjunctivitis/ Ligneous Membranitis
Mutation
c.1256+2T>A
Test Type
Genetic Disease/Disorder
Details
Ligneous membranitis (LM) is a rare chronic inflammatory condition of the mucous membranes. (as of 2015) The condition is uncommonly reported in dogs. For the research into this test, the researchers identified the risky genes using Scottish Terriers. Symptoms include: severe conjunctivitis, gingivitis, and respiratory distress. Hypoplasminogenaemia was confirmed in one of the three affected dogs. Supportive treatment was not effective, and the dogs died or were euthanased because of the disease. Post-mortem analysis of two of the dogs revealed multiple abnormalities including severe proliferative fibrinous lesions affecting the conjunctiva, gingiva, trachea, larynx and epicardium and multiple fibrous adhesions throughout the thoracic and abdominal cavities. One dog had internal hydrocephalus and lacked a cerebellar vermis. Ligneous membranitis was confirmed on histopathology. This is a rare condition in dogs but an important differential diagnosis for severe conjunctivitis and gingivitis.
Details 2
Ligneous membranitis (LM) is a rare chronic inflammatory condition of the mucous membranes associated with plasminogen (encoded by PLG) deficiency in affected humans and dogs...The condition is uncommonly reported in dogs... We identified related Scottish Terriers (littermates) with severe LM and unaffected relatives (sire, dam and a sibling from a previous litter). Plasma plasminogen activity was below normal in one affected dog but within normal reference intervals for the other... (From Ainsworth et al, 2015)
Published
Ainsworth, S., Carter, S., Fisher, C., Dawson, J., Makrides, L., Nuttall, T., Mason, S.L. : Ligneous membranitis in Scottish Terriers is associated with a single nucleotide polymorphism in the plasminogen (PLG) gene. Anim Genet 46:707-10, 2015. Pubmed reference: 26360520. DOI: 10.1111/age.12339.
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