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Neuropathy, Sensory


Relevance Rating: The test is unknown, there is no evidence (i.e. research) available, or it has not been evaluated yet. These tests may or may not be meaningful in this breed


Disease Name
Neuropathy, Sensory
6.47 Mb inversion
Test Type
Genetic Disease/Disorder
Sensory neuropathy (SN) causes severe, progressive degeneration of sensory and motor nerve cells. Signs include: knuckling of the feet, self-mutilation, excessive licking, progressive ataxia, and a progressive loss of sensation in limbs - progressing to include incontinence and regurgitation. Age of onset 2-7 months. As quality of life is severely affected, dogs with SN are euthanised before two years of age.
Details 2
Sensory neuropathy in the Border Collie is a severe neurological disorder caused by the degeneration of sensory and, to a lesser extent, motor nerve cells with clinical signs starting between 2 and 7 months of age... Through mutation screening, it should be possible to reduce the frequency of or completely eliminate this debilitating condition from the Border Collie breed population. (From Forman et al, 2017)
Forman, O.P., Hitti, R.J., Pettitt, L., Jenkins, C.A., O'Brien, D.P., Shelton, G.D., De Risio, L., Gutierrez Quintana, R., Beltran, E., Mellersh, C. : An Inversion Disrupting FAM134B Is Associated with Sensory Neuropathy in the Border Collie Dog Breed. G3 (Bethesda) :, 2016. Pubmed reference: 27527794. DOI: 10.1534/g3.116.027896.

Breed Specific Info

Breed-specific 1
Border Collie
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