Donate
Progressive Retinal Atrophy - Italian Greyhound
Breed: Italian Greyhound/ Piccolo Levriero Italiano
Generic Phene Data
Breeds
Relevance Rating: There is some evidence or research available in this breed
General
Disease Name
Progressive Retinal Atrophy - Italian Greyhound
OMIA
-32
Gene Name
unpublished
Mutation
unpublished
Test Type
Genetic Disease/Disorder
Details
A late-onset PRA, meaning that the first symptoms of retinal degeneration are not observed until the dog has reached maturity. Typically, signs are apparent between 3-5 years of age. The disease itself is painless but affected dogs should be regularly monitored by an ophthalmologist. As a progressive disease, first signs are loss of vision in dim light, followed by decreased vision in bright light conditions due, and eventually complete blindness.
Details 2
Considered late-onset. Typically, signs are apparent between 3-5 years of age. The symptoms of IG-PRA1 are very similar to other (unrelated) forms of late onset PRA such as prcd and crd3. Loss of retinal cells leads to increased reflectivity from the mirrored tapetal cells in the back of the eye and retinal vessels are pruned as the number of retinal cells needing to be nourished diminishes. Progressive, first blindness in dim light leading to complete blindness in all lights.
Published
Goldstein et al, publication in development (as of 2017)
Body/System/Process
Eye
Inheritance
ARIP
Breed Specific Info
Researched Breeds
Italian Greyhound
HSP Test-Specific Data
DNA My Dog
GTP
GTP Name
DNA My Dog
Breed
OMIA
Gene Name
unpublished
Mutation
unpublished
Nature of test
mutation test
Inheritance
AR
This test is outsourced to:
Orivet
FCI Number
200
GTP Breed
Italian Greyhound/ Piccolo levriero italiano
Orivet Genetic Pet Care
GTP
GTP Name
Orivet Genetic Pet Care
Breed
OMIA
Gene Name
unpublished
Mutation
unpublished
Nature of test
mutation test
Inheritance
AR
FCI Number
200
GTP Breed
Italian Greyhound/ Piccolo levriero italiano
Veterinary Genetics Laboratory
GTP
GTP Name
Veterinary Genetics Laboratory
Breed
OMIA
Gene Name
unpublished
Mutation
unpublished
Nature of test
risk profile
GTP- or Breed-Specific Publications
Unpublished
Application in the Breed
Progressive photoreceptor degeneration resulting in blindness
Inheritance
AR
FCI Number
200
GTP Breed
Italian Greyhound/ Piccolo levriero italiano
-
HGTD Quick Search
-
The portal for Genetic Testing Providers (labs); genetic tests, and tests by breed: as well as information on quality indicators and genetic counseling resources.
GOAL: Robust genetic testing supporting health improvements & a sustainable future for healthy dogs. -
HGTD Database Resources
How to use the HGTD
Using HGTD - YouTube Videos
HGTD Quality Indicators
Acronyms - Mode of Inheritance♦ 2020-New What is a Relevance Rating?
FAQs
Answers to frequently asked questions about the HGTD
Accreditation Basics
This brief overview may help you identify what types of accreditation are important to you, when choosing your genetic test provider.
Accreditation and Industry Standards
List of organizations throughout the world that are involved in matters of accreditation and establishing industry standards.
Choosing a Genetic Test Provider
Choosing a genetic test provider can be daunting. This short article helps you to consider what is important to you, and your dogs, in finding the right test provider for you. -
The HGTD's genetic counselling resources index provides access to basic introductory articles on genetics, articles on application of genetics in breed health management, and advanced work in technical genetics research. Breed-specific information is also available in our Pedigreed Dogs Database.
