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Progressive Retinal Atrophy - Italian Greyhound
Breeds
Relevance Rating: There is some evidence or research available in this breed
General
Disease Name
Progressive Retinal Atrophy - Italian Greyhound
OMIA
-32
Gene Name
unpublished
Mutation
unpublished
Test Type
Genetic Disease/Disorder
Details
A late-onset PRA, meaning that the first symptoms of retinal degeneration are not observed until the dog has reached maturity. Typically, signs are apparent between 3-5 years of age. The disease itself is painless but affected dogs should be regularly monitored by an ophthalmologist. As a progressive disease, first signs are loss of vision in dim light, followed by decreased vision in bright light conditions due, and eventually complete blindness.
Details 2
Considered late-onset. Typically, signs are apparent between 3-5 years of age. The symptoms of IG-PRA1 are very similar to other (unrelated) forms of late onset PRA such as prcd and crd3. Loss of retinal cells leads to increased reflectivity from the mirrored tapetal cells in the back of the eye and retinal vessels are pruned as the number of retinal cells needing to be nourished diminishes. Progressive, first blindness in dim light leading to complete blindness in all lights.
Published
Goldstein et al, publication in development (as of 2017)
Body/System/Process
Eye
Inheritance
ARIP
Breed Specific Info
Researched Breeds
Italian Greyhound
