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Acral Mutilation Syndrome


Relevance Rating: There is some evidence or research available for these breeds

Relevance Rating: The test is unknown, there is no evidence (i.e. research) available, or it has not been evaluated yet. These tests may or may not be meaningful for these breeds


Disease Name
Acral Mutilation Syndrome
Test Type
Genetic Disease/Disorder
A neurological disorder in which the nerves leading to the feet degenerate resulting in insensitivity to pain in legs and feet, sometimes accompanied by swelling, micro fractures, feet ulceration and discomfort. Affected dogs are prone to excessive licking, chewing and self-mutilation. The condition is sometimes detected soon after birth, typically symptoms become obvious by 4 -5 months.
Details 2
As summarised by Plassais et al. (2016): " Clinical signs appear in young puppies and consist of acral analgesia, with or without sudden intense licking, biting and severe self-mutilation of the feet, whereas proprioception, motor abilities and spinal reflexes remain intact"
Plassais J, Lagoutte L, Correard S, Paradis M, Guaguère E, Hédan B, et al. (2016) A Point Mutation in a lincRNA Upstream of GDNF Is Associated to a Canine Insensitivity to Pain: A Spontaneous Model for Human Sensory Neuropathies. PLoS Genet 2(12): e1006482.
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