The DVL2 variant appears to be associated with the "screw tail" (short, kinked tail) in a number of dog breeds/types. This variant may also be related to a Robinow-like syndrome, characterised by wide heads, flat caese and short-limbed dwarfism. The research establishes the likelihood that the variant is associated with caudal vertebral malformations (e.g. screw tail) and a brachycephalic conformation. There is some indication that this further links to brachycephalic obstructive airway syndrome and congenital heart defects. Screw-tail is an undesired trait in non-screw tail breeds, therefore screening of the DVL2 variant could help breeding plans to reduce unwanted DVL2-related risks. (ref. Niskanen et al. 2021) Inheritance pattern is suggested to be autosomal dominant, with incomplete penetrance, but in some breeds the variant may be fixed. While all indications appear that the DVL2 variant is important for screw-tail and likely risk-associated with brachycephalic conformation the severity of clinical signs may vary with breeds and individual dogs.