The MC5R-gene has been identified as a gene that can impact the degree of shedding in certain dog breeds. The variants of MCR5-gene disrupt the structure of sebum and result in increased shedding. There are two variants of this gene: A and G. The G-variant indicates a high degree of shedding. Dogs carrying one copy of this variant have increased shedding and dogs inheriting two copies of this variant have even higher degree of shedding. However, even a dog with no shedding cannot be guarenteed to be hypoallergenic. (credit: edited from Genomia's testing information)