Dilated Cardiomyopathy, (DCM) DCM4 variant; Doberman Pinscher
        
            Breeds
        
    
    
                
                Relevance Rating: There is some evidence or research available  in this breed 
                
            
            
        
        General
        
            Disease Name
        
    
    
            Dilated Cardiomyopathy, (DCM) DCM4 variant; Doberman Pinscher
            
        
        
        
            OMIA
        
    
    
            -112
            
        
        
        
            Gene Name
        
    
    
            DCM4
            
        
        
        
            Mutation
        
    
    
            chr5:60,531,090
            
        
        
        
            Test Type
        
    
    
            Genetic Disease/Disorder
            
        
        
        
            Details
        
    
    
            This is one risk variant associated with DCM in Dobermanns. DCM4 is considered the major variant, with an autosomal recessive effect. It is reported that this variant is potentially associated with risk for US populations of Dobermanns, but not associated with European populations. Recommendations are that Dobermanns from US populations should test for DCM1 and DCM2 in the first instance, and DCM3 and DCM4 in the second instance. Dobermanns from European populations should test for DCM3 and DCM4 (as of 2023). It should be noted that as this is a risk variant test, there are specific guidelines and recommendations for reducing risks for passing on this inherited disease and assessing the dog's individual risk. Generally, risk increases both with multiple copies of specific risk variants, and with more than one DCM risk variant.
            
        
        
        
            Application Information
        
    
    
            Recommendations are that Dobermanns from US populations should test for DCM1 and DCM2 in the first instance, and DCM3 and DCM4 in the second instance. Dobermanns from European populations should test for DCM3 and DCM4.
            
        
        
        
            Assay/Test Information
        
    
    
            Linkage
            
        
        
        
            Inheritance
        
    
    
            RVAR
            
        
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