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Canine Leukocyte Adhesion Deficiency (CLAD)

Breed: Irish Red Setter

Generic Phene Data

Breeds
Relevance Rating: There is moderate evidence or research available for these breeds
GTPs
Agrotis S.r.l.
Anicom Specialty Medical Institute Inc.
Animal Genetics Laboratory, SLU
Antagene
BioBank AS
Generatio GmbH Center for Animal Genetics
Certagen GmbH
CMSCH
DNA My Dog
Embark
EVG Diagnostics
Genomia s.r.o
INNO
Laboklin Gmbh & Co. KG
Laboratorios Labocor S.L.
Orivet Genetic Pet Care
Paw Print Genetics
PharmaDNA
Progènes-ADN
The Kennel Club
Veterinary Genetics Laboratory
VetGen LLC
VHL Genetics
Weatherbys Scientific
Zoolyx

General

Disease Name
Canine Leukocyte Adhesion Deficiency (CLAD)
OMIA
595
Gene Name
ITGB2
Mutation
c.107G>C
Test Type
Genetic Disease/Disorder
Synonyms/Related Terms
Canine Leukocyte Adhesion Deficiency Type I, CLAD, FLAD, Feline Leukocyte Adhesion Deficiency
Details
Canine Leukocyte Adhesion Deficiency (CLAD), this rare but devastating condition is an inherited fatal immunodeficiency disease.This disorder affects the white blood cells ability to fight infection and is caused by misshapen proteins being formed on the surface of white blood cells. These proteins usually help the white blood cells to stick to each other and other cells in order to initiate an immune response to fight infections. Affected puppies white blood cells will not be as sticky and will not be able to fight infections as effectively. Age of onset is from birth. CLAD is characterized by recurrent, severe bacterial infections; impaired pus formation; and delayed wound healing. Infected animals usually have severe pyrexia (fever), loss of appetite and weight loss; response to antibiotic therapy is usually poor. Pups that inherit two recessive genes for CLAD usually die early in life from multiple severe infections, even when treated with massive doses of antibiotics.
Details 2
Canine Leukocyte Adhesion Deficiency (CLAD), this rare but devastating condition is an inherited fatal immunodeficiency disease.This disorder affects the white blood cells ability to fight infection and is caused by misshapen proteins being formed on the surface of white blood cells. These proteins usually help the white blood cells to stick to each other and other cells in order to initiate an immune response to fight infections. Affected puppies white blood cells will not be as sticky and will not be able to fight infections as effectively. Age of onset is from birth. CLAD is characterized by recurrent, severe bacterial infections; impaired pus formation; and delayed wound healing. Infected animals usually have severe pyrexia (fever), recurrent infections, neonatal omphalophlebitis, anorexia, lameness, impaired wound healing, severe skin infections, gingivitis, salivation, thickened mandible, enlarged metaphyses of the distal radius, ulna, tibia, and fibula, lameness, enlarged lymph nodes, and low body weight. Response to antibiotic therapy is usually poor. Pups that inherit two recessive genes for CLAD usually die early in life from multiple severe infections, even when treated with massive doses of antibiotics.
Patents/ Licences
Licenses held: Optigen. Test Developers: Swedish University in Uppsala, Sweden (Publication: 1) (please note that patent and licensing laws and coverage vary by country)
Published
Kijas, J.M.H., Bauer, T.R., Gafvert, S., Marklund, S., Trowald-Wigh, G., Johannisson, A., Hedhammar, A., Binns, M., Juneja, R.K., Hickstein, D.D., Andersson, L.: A missense mutation in the beta-2 integrin gene (ITGB2) causes canine leukocyte adhesion deficiency Genomics 61:101-107, 1999. Pubmed reference: 10512685. DOI: 10.1006/geno.1999.5948.
Published 2
Zimmerman, K.L., McMillan, K., Monroe, W.E., Sponenberg, D.P., Evans, N., Makris, M., Hammond, S.H., Kanevsky Mullarky, I., Boudreaux, M.K. : Leukocyte adhesion deficiency type I in a mixed-breed dog. J Vet Diagn Invest 25:291-6, 2013. Pubmed reference: 23417082. DOI: 10.1177/1040638713478814.
Body/System/Process
Autoimmune
Inheritance
AR

HSP Test-Specific Data

Agrotis S.r.l.

GTP
GTP Name
Agrotis S.r.l.
Breed
OMIA
Gene Name
ITGB2
Mutation
c.107G>C

Anicom Specialty Medical Institute Inc.

GTP
GTP Name
Anicom
Breed
OMIA
GTP Disease Name
Leukocyte adhesion deficiency, type I
Gene Name
ITGB2
Mutation
c.107G>C

Antagene

GTP
GTP Name
Antagene
Breed
OMIA
GTP Disease Name
Leukocyte adhesion deficiency, type I
GTP Disease Synonym
Canine Leukocyte Adhesion Deficiency Type I, CLAD, FLAD, Feline Leukocyte Adhesion Deficiency
Gene Name
ITGB2
Mutation
c.107G>C
Nature of test
mutation test
GTP- or Breed-Specific Publications
Kijas, J.M.H., Bauer, T.R., Gafvert, S., Marklund, S., Trowald-Wigh, G., Johannisson, A., Hedhammar, A., Binns, M., Juneja, R.K., Hickstein, D.D., Andersson, L.: A missense mutation in the beta-2 inte
Application in the Breed
Carriers may be bred to normal animals (N/clad x N/N) . Offspring should be tested before breeding. No breeding two carriers (N/clad x N/clad) nor of affected animals (clad/clad). Pups exhibit recurrent infections, slow wound healing , low body weight, lack of appetite, lameness, enlarged longbone growth plates, and fever. Death around 6 months of age.
Inheritance
AR
FCI Number
120
GTP Breed
Irish red Setter

BioBank AS

GTP
GTP Name
BioBank AS
Breed
OMIA
Gene Name
ITGB2
Mutation
c.107G>C

Generatio GmbH Center for Animal Genetics

GTP
GTP Name
Generatio GmbH Center for Animal Genetics
Breed
OMIA
GTP Disease Name
Leukocyte adhesion deficiency, type I
GTP Disease Synonym
Canine Leukocyte Adhesion Deficiency Type I, CLAD, FLAD, Feline Leukocyte Adhesion Deficiency
Gene Name
ITGB2
Mutation
c.107G>C

Certagen GmbH

GTP
GTP Name
Certagen GmbH
Breed
OMIA
Gene Name
ITGB2
Mutation
c.107G>C

CMSCH

GTP
GTP Name
CMSCH
Breed
OMIA
Gene Name
ITGB2
Mutation
c.107G>C

DNA My Dog

GTP
GTP Name
DNA My Dog
Breed
OMIA
GTP Disease Name
Leukocyte adhesion deficiency, type I
GTP Disease Synonym
Canine Leukocyte Adhesion Deficiency Type I, CLAD, FLAD, Feline Leukocyte Adhesion Deficiency
Gene Name
ITGB2
Mutation
c.107G>C
Nature of test
mutation test
GTP- or Breed-Specific Publications
Kijas, J.M.H., Bauer, T.R., Gafvert, S., Marklund, S., Trowald-Wigh, G., Johannisson, A., Hedhammar, A., Binns, M., Juneja, R.K., Hickstein, D.D., Andersson, L.: A missense mutation in the beta-2 inte
Application in the Breed
Carriers may be bred to normal animals (N/clad x N/N) . Offspring should be tested before breeding. No breeding two carriers (N/clad x N/clad) nor of affected animals (clad/clad). Pups exhibit recurrent infections, slow wound healing , low body weight, lack of appetite, lameness, enlarged longbone growth plates, and fever. Death around 6 months of age.
Inheritance
AR
This test is outsourced to:
Orivet
FCI Number
120
GTP Breed
Irish red Setter

Embark

GTP
GTP Name
Embark
Breed
OMIA
GTP Disease Name
Leukocyte adhesion deficiency, type I
GTP Disease Synonym
Canine Leukocyte Adhesion Deficiency Type I, CLAD, FLAD, Feline Leukocyte Adhesion Deficiency
Gene Name
ITGB2
Mutation
c107G>C
Nature of test
mutation test
GTP- or Breed-Specific Publications
Kijas, J.M.H., Bauer, T.R., Gafvert, S., Marklund, S., Trowald-Wigh, G., Johannisson, A., Hedhammar, A., Binns, M., Juneja, R.K., Hickstein, D.D., Andersson, L.: A missense mutation in the beta-2 inte
Application in the Breed
Carriers may be bred to normal animals (N/clad x N/N) . Offspring should be tested before breeding. No breeding two carriers (N/clad x N/clad) nor of affected animals (clad/clad). Pups exhibit recurrent infections, slow wound healing , low body weight, lack of appetite, lameness, enlarged longbone growth plates, and fever. Death around 6 months of age.
Inheritance
AR
FCI Number
120
GTP Breed
Irish red Setter

EVG Diagnostics

GTP
GTP Name
EVG Molecular Diagnostics
Breed
OMIA
Gene Name
ITGB2
Mutation
c.107G>C

Genomia s.r.o

GTP
GTP Name
Genomia s.r.o
Breed
OMIA
GTP Disease Name
Leukocyte adhesion deficiency, type I
Gene Name
ITGB2
Mutation
c.107G>C
Mutation Comment
g.38537012C>G
Nature of test
mutation test
FCI Number
120
GTP Breed
Irish red Setter

INNO

GTP
GTP Name
INNO
Breed
OMIA
Gene Name
ITGB2
Mutation
c.107G>C

The Kennel Club

GTP
GTP Name
The Kennel Club
Breed
OMIA
GTP Disease Name
Leukocyte adhesion deficiency, type I
Gene Name
ITGB2
Mutation
c.107G>C
This test is outsourced to:
Weatherby's

Laboratorios Labocor S.L.

GTP
GTP Name
Laboratorios Labocor S.L.
Breed
OMIA
Gene Name
ITGB2
Mutation
c.107G>C

Laboklin Gmbh & Co. KG

GTP
GTP Name
Laboklin Gmbh & Co. KG
Breed
OMIA
GTP Disease Name
Leukocyte adhesion deficiency, type I
GTP Disease Synonym
Canine Leukocyte Adhesion Deficiency Type I, CLAD, FLAD, Feline Leukocyte Adhesion Deficiency
Gene Name
ITGB2
Mutation
c.107G>C
Nature of test
mutation test
GTP- or Breed-Specific Publications
Kijas, J.M.H., Bauer, T.R., Gafvert, S., Marklund, S., Trowald-Wigh, G., Johannisson, A., Hedhammar, A., Binns, M., Juneja, R.K., Hickstein, D.D., Andersson, L.: A missense mutation in the beta-2 inte
Application in the Breed
Carriers may be bred to normal animals (N/clad x N/N) . Offspring should be tested before breeding. No breeding two carriers (N/clad x N/clad) nor of affected animals (clad/clad). Pups exhibit recurrent infections, slow wound healing , low body weight, lack of appetite, lameness, enlarged longbone growth plates, and fever. Death around 6 months of age.
Inheritance
AR
FCI Number
120
GTP Breed
Irish red Setter

Orivet Genetic Pet Care

GTP
GTP Name
Orivet Genetic Pet Care
Breed
OMIA
GTP Disease Name
Leukocyte adhesion deficiency, type I
GTP Disease Synonym
Canine Leukocyte Adhesion Deficiency Type I, CLAD, FLAD, Feline Leukocyte Adhesion Deficiency
Gene Name
ITGB2
Mutation
c.107G>C
Nature of test
mutation test
GTP- or Breed-Specific Publications
Kijas, J.M.H., Bauer, T.R., Gafvert, S., Marklund, S., Trowald-Wigh, G., Johannisson, A., Hedhammar, A., Binns, M., Juneja, R.K., Hickstein, D.D., Andersson, L.: A missense mutation in the beta-2 inte
Application in the Breed
Carriers may be bred to normal animals (N/clad x N/N) . Offspring should be tested before breeding. No breeding two carriers (N/clad x N/clad) nor of affected animals (clad/clad). Pups exhibit recurrent infections, slow wound healing , low body weight, lack of appetite, lameness, enlarged longbone growth plates, and fever. Death around 6 months of age.
Inheritance
AR
FCI Number
120
GTP Breed
Irish red Setter

Paw Print Genetics

GTP
GTP Name
Paw Print Genetics
Breed
OMIA
GTP Disease Name
Leukocyte Adhesion Deficiency, Type I
Gene Name
ITGB2
Mutation
c.107G>C
Nature of test
mutation test
FCI Number
120

PharmaDNA

GTP
GTP Name
PharmaDNA
Breed
OMIA
Gene Name
ITGB2
Mutation
c.107G>C

Progènes-ADN

GTP
GTP Name
Progenes ADN
Breed
OMIA
Gene Name
ITGB2
Mutation
c.107G>C

Animal Genetics Laboratory, SLU

GTP
GTP Name
Animal Genetics Laboratory SLU
Breed
OMIA
GTP Disease Name
Leukocyte Adhesion Deficiency, Type I
Gene Name
ITGB2
Mutation
c.107G>C
Nature of test
mutation test
FCI Number
120

Veterinary Genetics Laboratory

GTP
GTP Name
Veterinary Genetics Laboratory
Breed
OMIA
GTP Disease Name
Leukocyte Adhesion Deficiency, Type I
Gene Name
ITGB2
Mutation
c.107G>C
Nature of test
mutation test

VetGen LLC

GTP
GTP Name
VetGen LLC
Breed
OMIA
Gene Name
ITGB2
Mutation
c.107G>C

VHL Genetics

GTP
GTP Name
VHL Genetics
Breed
OMIA
Gene Name
ITGB2
Mutation
c.107G>C

Zoolyx

GTP
GTP Name
Zoolyx
Breed
OMIA
Gene Name
ITGB2
Mutation
c.107G>C

Weatherbys Scientific

GTP
GTP Name
Weatherbys Scientific
Breed
OMIA
GTP Disease Name
Leukocyte adhesion deficiency, type I
Gene Name
ITGB2
Mutation
c.107G>C
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