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Cardiomyopathy and juvenile mortality

Breed: Belgian Shepherd Dog/ Groenendael

Generic Phene Data

Breeds

Relevance Rating: There is some evidence or research available for these breeds

Belgian Shepherd Dog/ Groenendael

Belgian Shepherd Dog/ Laekenois

Belgian Shepherd Dog/ Malinois

Belgian Shepherd Dog/ Tervueren

GTPs

Laboklin Gmbh & Co. KG

No Test/Unknown GTP availability

General

Disease Name

Cardiomyopathy and juvenile mortality

OMIA

2256

Gene Name

YARS2

Mutation

no test 2020

Mutation 2

g.16157324A>G

Mutation 3

c.1054G>A

Mutation 4

p.(E352K)

Test Type

Genetic Disease/Disorder

Published

2020 Gurtner, C., Hug, P., Kleiter, M., Köhler, K., Dietschi, E., Jagannathan, V., Leeb, T. : YARS2 Missense Variant in Belgian Shepherd Dogs with Cardiomyopathy and Juvenile Mortality. Genes (Basel) 11:, 2020. Pubmed reference: 32183361. DOI: 10.3390/genes11030313.

OMIA Url

https://omia.org/OMIA002256/9615/

Inheritance

AR

Breed Specific Info

Researched Breeds

Belgian Shepherd

Key Comment

The origional research referenced Malinois variety specifically in the investigation, but this test is considered relevant to all varieties due to current and historical interbreeding, and the investigation including a genomic survey of 400+ dogs across all types.

HSP Test-Specific Data

Laboklin Gmbh & Co. KG

GTP

GTP Name

Laboklin Gmbh & Co. KG

Breed

OMIA

Gene Name

YARS2

Mutation

g.16157324A>G, c.1054G>A, p.(E352K)

FCI Number

15

No Test/Unknown GTP availability

GTP

Breed

OMIA

Gene Name

YARS2

Genomia s.r.o

GTP

GTP Name

Genomia s.r.o

Breed

OMIA

Gene Name

YARS2

Mutation

c.1054G>A

Mutation Comment

g.16157324A>G

FCI Number

15

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