Cleft Palate
        
            Breeds
        
    
    
                
                Relevance Rating: There is some evidence or research available  in this breed 
                
            
            
        
        General
        
            Disease Name
        
    
    
            Cleft Palate
            
        
        
        
            OMIA
        
    
    
            1919
            
        
        
        
            Gene Name
        
    
    
            DLX6
            
        
        
        
            Mutation
        
    
    
            cfa14.25016716ins2056bp L1
            
        
        
        
            Test Type
        
    
    
            Genetic Disease/Disorder
            
        
        
        
            Details
        
    
    
            A cleft palate is an abnormal opening in the roof of the mouth. It is the result of failure of the two sides of the palate (roof of the mouth) to come together and fuse during embryonic development. A cleft palate results in an opening between the nasal passages and the mouth. Symptoms expected with a cleft palate include: runny nose, coughing, aspiration pneumonia (pneumonia caused by milk and food contents entering the cleft and infecting the lungs), respiratory difficulty (caused by aspiration pneumonia), difficulty sucking and nursing (for puppies), slow growth, weight loss, lack of appetite. Cleft palates can be inherited, and also have non-inherited causes, such as environmental effects - i.e. vitamin deficencies.
            
        
        
        
            Details 2
        
    
    
            Cleft lip (often referred to incorrectly as a ?hair lip? or more appropriately as palatoschisis or congenital oronasal fistula) and cleft palate are birth defects that occur when a puppy's lip or mouth do not form properly during pregnancy. Symptoms with a cleft palate can include: runny nose, coughing, aspiration pneumonia, respiratory difficulty (caused by aspiration pneumonia), difficulty sucking and nursing, slow growth, weight loss, lack of appetite. Cleft palates can be inherited, and also have non-inherited causes, such as environmental effects.
            
        
        
        
            Published
        
    
    
            Wolf, Z.T., Leslie, E.J., Arzi, B., Jayashankar, K., Karmi, N., Jia, Z., Rowland, D.J., Young, A., Safra, N., Sliskovic, S., Murray, J.C., Wade, C.M., Bannasch, D.L. : A LINE-1 Insertion in DLX6 Is Responsible for Cleft Palate and Mandibular Abnormalities in a Canine Model of Pierre Robin Sequence. PLoS Genet 10:e1004257, 2014. Pubmed reference: 24699068. DOI: 10.1371/journal.pgen.1004257.
            
        
        
        
            Published 2
        
    
    
            Peralta, S., Fiani, N., Kan-Rohrer, K.H., Verstraete, F.J.M. : Morphological evaluation of clefts of the lip, palate, or both in dogs. Am J Vet Res 78:926-933, 2017. Pubmed reference: 28738009. DOI: 10.2460/ajvr.78.8.926.
            
        
        
        
            Body/System/Process
        
    
    
            Anatomic
            
        
        
        
            OMIA Url
        
    
    
        
            Inheritance
        
    
    
            AR
            
        
        Breed Specific Info
        
            Researched Breeds
        
    
    
            Nova Scotia Duck Tolling Retriever
            
        
         Donate
                Donate