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Coat Colour, Agouti

Breeds

Relevance Rating: Unknown, not evaluated or no evidence for test in this breed

ALL

General

Disease Name
Coat Colour, Agouti
Mutation
c.244G>T
Mutation 2
p.A82S
Test Type
Other Genetic Traits
Details
Agouti consists of four alleles: sable (Ay), agouti (aw), tan points (at), recessive black (a). Agouti alleles control which cells produce eumelanin (black or modified black pigment) and, for (aw), when. Please note that a dominant black dog may be genetically a sable, tan-point or agouti, but it will not be able to display it. In some breeds it's thought that the A locus genes may display incomplete dominance, with the appearance of the dog being affected by its more recessive allele as well as the more dominant one.
Details 2
Agouti consists of four alleles: sable (Ay), agouti (aw), tan points (at), recessive black (a). Agouti alleles control which cells produce eumelanin (black or modified black pigment) and, for (aw), when. Please note that a dominant black dog may be genetically a sable, tan-point or agouti, but it will not be able to display it. In some breeds it's thought that the A locus genes may display incomplete dominance, with the appearance of the dog being affected by its more recessive allele as well as the more dominant one.
Published
Kerns, JA., Newton, J., Berryere, TG., Rubin, EM., Cheng, JF., Schmutz, SM., Barsh, GS. : Characterization of the dog Agouti gene and a nonagoutimutation in German Shepherd Dogs. Mamm Genome 15:798-808, 2004. Pubmed reference: 15520882. DOI: 10.1007/s00335-004-2377-1.
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