Craniomandibular Osteopathy
        
            Breeds
        
    
    
                
                Relevance Rating: There is some evidence or research available  for these breeds 
                
            
            
            
                
                Relevance Rating: The test is unknown, there is no evidence (i.e. research) available, or it has not been evaluated yet. These tests may or may not be meaningful  for these breeds 
                
            
            
        
        
        
            GTPs
        
    
    General
        
            Disease Name
        
    
    
            Craniomandibular Osteopathy
            
        
        
        
            OMIA
        
    
    
            2244
            
        
        
        
            Gene Name
        
    
    
            SLC37A2
            
        
        
        
            Mutation
        
    
    
            c.1332C>T
            
        
        
        
            Test Type
        
    
    
            Genetic Disease/Disorder
            
        
        
        
            Details
        
    
    
            Craniomandibular Osteopathy (CMO) is a disease causing extensive developmental changes in the bones of the skull and jaw. Symptoms include hard swelling and thickening of the jaw to the point of the mouth cannot fully open, drooling, severe pain and reoccuring tenderness, and difficulty eating. Treatment is limited to managing the symptoms. Inability to eat can cause malnutrition, and this, coupled with pain or difficulty with treatment can lead to a dog being euthanised.
            
        
        
        
            Details 2
        
    
    
            A four-month-old West Highland White Terrier was presented to the Small Animal Teaching Hospital at the University of Liverpool with the complaint of a bilateral angular carpal deformity. A 20° valgus deformity was present in both thoracic limbs, centred on the distal radial physes. Both distal ulnas were grossly thickened and there was concomitant thickening of the rostral mandible and calvarium. The dog exhibited signs of resentment on palpation of the mandible and signs of pain were elicited on flexion and extension of both elbow joints. No signs of pain were evident on palpation of the ulnas or calvarium. Radiographic images of both ulnas showed marked amorphous periosteal new bone formation. The distal ulnar physes were closed centrally and both elbow joints had humeroulnar subluxation. Radiographic changes to the calvarium and mandibular rami were consistent with a diagnosis of craniomandibular osteopathy. A bilateral ulna ostectomy was performed to correct the angular limb deformity and elbow subluxations. Histology of the ostectomised pieces showed changes consistent with craniomandibular osteopathy. (Pettitt et al, 2012)
            
        
        
        
            Published
        
    
    
            Pettitt, R., Fox, R., Comerford, E.J., Newitt, A. : Bilateral angular carpal deformity in a dog with craniomandibular osteopathy. Vet Comp Orthop Traumatol 25:149-54, 2012. Pubmed reference: 22366888. DOI: 10.3415/VCOT-11-02-0022.
            
        
        
        
            Published 2
        
    
    
            Hytönen, M.K., Arumilli, M., Lappalainen, A.K., Owczarek-Lipska, M., Jagannathan, V., Hundi, S., Salmela, E., Venta, P., Sarkiala, E., Jokinen, T., Gorgas, D., Kere, J., Nieminen, P., Drögemüller, C., Lohi, H. : Molecular Characterization of Three Canine Models of Human Rare Bone Diseases: Caffey, van den Ende-Gupta, and Raine Syndromes. PLoS Genet 12:e1006037, 2016. Pubmed reference: 27187611. DOI: 10.1371/journal.pgen.1006037.
            
        
        
        
            Published 3
        
    
    
            Donner, J., Kaukonen, M., Anderson, H., Móller, F., Kyóstilä, K., Sankari, S., Hytónen, M., Giger, U., Lohi, H. : Genetic Panel Screening of Nearly 100 Mutations Reveals New Insights into the Breed Di
            
        
        
        
            Body/System/Process
        
    
    
            Skeletal
            
        
        
        
            OMIA Url
        
    
    
        
            Inheritance
        
    
    
            ADIP
            
        
        Breed Specific Info
        
            Researched Breeds
        
    
    
            Cairn Terrier, Scottish Terrier, West Highland White terrier
            
        
         Donate
                Donate