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Dental Hypomineralization
Breeds
Relevance Rating: There is some evidence or research available in this breed
General
Disease Name
Dental Hypomineralization
OMIA
2015
Gene Name
FAM20C
Mutation
c.899C>T
Test Type
Genetic Disease/Disorder
Details
Canine dental hypomineralization or Raine Syndrom causes severe tooth wear resulting in pulpitis and requiring extraction of those teeth. Enamel has a light brown discoloration and appears dull, also worn and cracked in some cases. Chronic tooth inflamation, and loss is common. Clinical analyses show severe hypomineralization of teeth in affected dogs. Age of onset, symptoms observed from development of permanent teeth. Considered rare.
Details 2
Canine dental hypomineralization or Raine Syndrom causes severe tooth wear resulting in pulpitis and requiring extraction of those teeth. Enamel has a light brown discoloration and appears dull, also worn and cracked in some cases. Chronic tooth inflamation, and loss is common. Clinical analyses show severe hypomineralization of teeth in affected dogs. Age of onset, symptoms observed from development of permanent teeth. Considered rare.
Published
Hytönen, M.K., Arumilli, M., Lappalainen, A.K., Owczarek-Lipska, M., Jagannathan, V., Hundi, S., Salmela, E., Venta, P., Sarkiala, E., Jokinen, T., Gorgas, D., Kere, J., Nieminen, P., Drögemüller, C., Lohi, H. : Molecular Characterization of Three Canine Models of Human Rare Bone Diseases: Caffey, van den Ende-Gupta, and Raine Syndromes. PLoS Genet 12:e1006037, 2016. Pubmed reference: 27187611. DOI: 10.1371/journal.pgen.1006037.
Published 2
Hytönen, M.K., Lohi, H. : Canine models of human rare disorders. Rare Dis 4:e1241362, 2016. Pubmed reference: 27803843. DOI: 10.1080/21675511.2016.1241362.
Body/System/Process
Teeth
OMIA Url
Inheritance
AR
Breed Specific Info
Researched Breeds
Border Collie
