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Dental Hypomineralization
Breed: Border Collie
Generic Phene Data
Breeds
Relevance Rating: There is some evidence or research available in this breed
General
Disease Name
Dental Hypomineralization
OMIA
2015
Gene Name
FAM20C
Mutation
c.899C>T
Test Type
Genetic Disease/Disorder
Details
Canine dental hypomineralization or Raine Syndrom causes severe tooth wear resulting in pulpitis and requiring extraction of those teeth. Enamel has a light brown discoloration and appears dull, also worn and cracked in some cases. Chronic tooth inflamation, and loss is common. Clinical analyses show severe hypomineralization of teeth in affected dogs. Age of onset, symptoms observed from development of permanent teeth. Considered rare.
Details 2
Canine dental hypomineralization or Raine Syndrom causes severe tooth wear resulting in pulpitis and requiring extraction of those teeth. Enamel has a light brown discoloration and appears dull, also worn and cracked in some cases. Chronic tooth inflamation, and loss is common. Clinical analyses show severe hypomineralization of teeth in affected dogs. Age of onset, symptoms observed from development of permanent teeth. Considered rare.
Published
Hytönen, M.K., Arumilli, M., Lappalainen, A.K., Owczarek-Lipska, M., Jagannathan, V., Hundi, S., Salmela, E., Venta, P., Sarkiala, E., Jokinen, T., Gorgas, D., Kere, J., Nieminen, P., Drögemüller, C., Lohi, H. : Molecular Characterization of Three Canine Models of Human Rare Bone Diseases: Caffey, van den Ende-Gupta, and Raine Syndromes. PLoS Genet 12:e1006037, 2016. Pubmed reference: 27187611. DOI: 10.1371/journal.pgen.1006037.
Published 2
Hytönen, M.K., Lohi, H. : Canine models of human rare disorders. Rare Dis 4:e1241362, 2016. Pubmed reference: 27803843. DOI: 10.1080/21675511.2016.1241362.
Body/System/Process
Teeth
OMIA Url
Inheritance
AR
Breed Specific Info
Researched Breeds
Border Collie
HSP Test-Specific Data
Agrotis S.r.l.
GTP
GTP Name
Agrotis S.r.l.
Breed
OMIA
Gene Name
FAM20C
Mutation
c.899C>T
BioBank AS
GTP
GTP Name
BioBank AS
Breed
OMIA
Gene Name
FAM20C
Mutation
c.899C>T
Generatio GmbH Center for Animal Genetics
GTP
GTP Name
Generatio GmbH Center for Animal Genetics
Breed
OMIA
GTP Disease Name
Raine Syndrome
Gene Name
FAM20C
Mutation
c.899C>T
Certagen GmbH
GTP
GTP Name
Certagen GmbH
Breed
OMIA
Gene Name
FAM20C
Mutation
c.899C>T
CMSCH
GTP
GTP Name
CMSCH
Breed
OMIA
Gene Name
FAM20C
Mutation
c.899C>T
EVG Diagnostics
GTP
GTP Name
EVG Molecular Diagnostics
Breed
OMIA
Gene Name
FAM20C
Mutation
c.899C>T
Genomia s.r.o
GTP
GTP Name
Genomia s.r.o
Breed
OMIA
GTP Disease Synonym
Raine Syndrome
Gene Name
FAM20C
Mutation
c.899C>T
Mutation Comment
g.16452327G>A
Nature of test
mutation test
FCI Number
297
GTP Breed
Border Collie
INNO
GTP
GTP Name
INNO
Breed
OMIA
Gene Name
FAM20C
Mutation
c.899C>T
Laboratorios Labocor S.L.
GTP
GTP Name
Laboratorios Labocor S.L.
Breed
OMIA
Gene Name
FAM20C
Mutation
c.899C>T
Laboklin Gmbh & Co. KG
GTP
GTP Name
Laboklin Gmbh & Co. KG
Breed
OMIA
GTP Disease Synonym
Raine Syndrome
Gene Name
FAM20C
Mutation
c.899C>T
Nature of test
mutation test
FCI Number
297
PharmaDNA
GTP
GTP Name
PharmaDNA
Breed
OMIA
Gene Name
FAM20C
Mutation
c.899C>T
Progènes-ADN
GTP
GTP Name
Progenes ADN
Breed
OMIA
Gene Name
FAM20C
Mutation
c.899C>T
VetGen LLC
GTP
GTP Name
VetGen LLC
Breed
OMIA
Gene Name
FAM20C
Mutation
c.899C>T
VHL Genetics
GTP
GTP Name
VHL Genetics
Breed
OMIA
Gene Name
FAM20C
Mutation
c.899C>T
Weatherbys Scientific
GTP
GTP Name
Weatherbys Scientific
Breed
OMIA
GTP Disease Name
Raine Syndrome
Gene Name
FAM20C
Mutation
c.899C>T
Wisdom Panel - Kinship
GTP
GTP Name
Wisdom Panel - Kinship
Breed
OMIA
GTP Disease Synonym
Raine Syndrome
Gene Name
FAM20C
Mutation
c.899C>T
Nature of test
mutation test
FCI Number
297
GTP Breed
Border Collie
Zoolyx
GTP
GTP Name
Zoolyx
Breed
OMIA
Gene Name
FAM20C
Mutation
c.899C>T
AnimaLabs
GTP
GTP Name
AnimaLabs
Breed
OMIA
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