Dental Hypomineralization
        
            Breeds
        
    
    
                
                Relevance Rating: There is some evidence or research available  in this breed 
                
            
            
        
        General
        
            Disease Name
        
    
    
            Dental Hypomineralization
            
        
        
        
            OMIA
        
    
    
            2015
            
        
        
        
            Gene Name
        
    
    
            FAM20C
            
        
        
        
            Mutation
        
    
    
            c.899C>T
            
        
        
        
            Test Type
        
    
    
            Genetic Disease/Disorder
            
        
        
        
            Details
        
    
    
            Canine dental hypomineralization or Raine Syndrom causes severe tooth wear resulting in pulpitis and requiring extraction of those teeth. Enamel has a light brown discoloration and appears dull, also worn and cracked in some cases. Chronic tooth inflamation, and loss is common. Clinical analyses show severe hypomineralization of teeth in affected dogs. Age of onset, symptoms observed from development of permanent teeth. Considered rare.
            
        
        
        
            Details 2
        
    
    
            Canine dental hypomineralization or Raine Syndrom causes severe tooth wear resulting in pulpitis and requiring extraction of those teeth. Enamel has a light brown discoloration and appears dull, also worn and cracked in some cases. Chronic tooth inflamation, and loss is common. Clinical analyses show severe hypomineralization of teeth in affected dogs. Age of onset, symptoms observed from development of permanent teeth. Considered rare.
            
        
        
        
            Published
        
    
    
            Hytönen, M.K., Arumilli, M., Lappalainen, A.K., Owczarek-Lipska, M., Jagannathan, V., Hundi, S., Salmela, E., Venta, P., Sarkiala, E., Jokinen, T., Gorgas, D., Kere, J., Nieminen, P., Drögemüller, C., Lohi, H. : Molecular Characterization of Three Canine Models of Human Rare Bone Diseases: Caffey, van den Ende-Gupta, and Raine Syndromes. PLoS Genet 12:e1006037, 2016. Pubmed reference: 27187611. DOI: 10.1371/journal.pgen.1006037.
            
        
        
        
            Published 2
        
    
    
            Hytönen, M.K., Lohi, H. : Canine models of human rare disorders. Rare Dis 4:e1241362, 2016. Pubmed reference: 27803843. DOI: 10.1080/21675511.2016.1241362.
            
        
        
        
            Body/System/Process
        
    
    
            Teeth
            
        
        
        
            OMIA Url
        
    
    
        
            Inheritance
        
    
    
            AR
            
        
        Breed Specific Info
        
            Researched Breeds
        
    
    
            Border Collie
            
        
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