Donate
Factor VIII Deficiency
Breed: German Shepherd Dog/ Double coat
Generic Phene Data
Breeds
Relevance Rating: There is some evidence or research available for these breeds
Relevance Rating: The test is unknown, there is no evidence (i.e. research) available, or it has not been evaluated yet. These tests may or may not be meaningful in this breed
GTPs
General
Disease Name
Factor VIII Deficiency
OMIA
437
Gene Name
FVIII
Mutation
c.1412C>G
Mutation 2
c.1643G>A
Mutation 3
p.Cys548Tyr
Test Type
Genetic Disease/Disorder
Details
Factor XIII deficiency causes an impaired coagulability of the blood, with a consequential strong tendency to bleed, due to a deficiency of clotting factor VIII. Since the gene for this factor is located on the X chromosome, the disorder is expected to be X-linked.
Details 2
Factor XIII deficiency causes an impaired coagulability of the blood, with a consequential strong tendency to bleed, due to a deficiency of clotting factor VIII. Since the gene for this factor is located on the X chromosome, the disorder is expected to be X-linked.
Published
Hough, C., Kamisue, S., Cameron, C., Notley, C., Tinlin, S., Giles, A., Lillicrap, D. : Aberrant splicing and premature termination of transcription of the FVIII gene as a cause of severe canine hemophilia A: Similarities with the intron 22 inversion mutation in human hemophilia Thrombosis & Haemostasis 87:659-665, 2002. Pubmed reference: 12008949.
Published 2
Lozier, J.N., Nichols, T.C. : Animal Models of Hemophilia and Related Bleeding Disorders. Semin Hematol 50:175-184, 2013. Pubmed reference: 23956467. DOI: 10.1053/j.seminhematol.2013.03.023.
Published 3
Lozier, J.N., Dutra, A., Pak, E., Zhou, N., Zheng, Z.L., Nichols, T.C., Bellinger, D.A., Read, M., Morgan, R.A. : The Chapel Hill hemophilia A dog colony exhibits a factor VIII gene inversion Proceedings of the National Academy of Sciences of the United States of America 99:12991-12996, 2002. Pubmed reference: 12242334. DOI: 10.1073/pnas.192219599.
Body/System/Process
Blood
OMIA Url
Inheritance
XR
Breed Specific Info
Researched Breeds
Boxer
HSP Test-Specific Data
Laboratorios Labocor S.L.
GTP
GTP Name
Laboratorios Labocor S.L.
Breed
OMIA
Gene Name
FVIII
Mutation
c.98G>A; c.1412C>G; c.1643G>A; c.1643G>A
Certagen GmbH
GTP
GTP Name
Certagen GmbH
Breed
OMIA
Gene Name
FVIII
Mutation
c.98G>A; c.1412C>G; c.1643G>A; c.1643G>A
VHL Genetics
GTP
GTP Name
VHL Genetics
Breed
OMIA
Gene Name
FVIII
Mutation
c.98G>A; c.1412C>G; c.1643G>A; c.1643G>A
Zoolyx
GTP
GTP Name
Zoolyx
Breed
OMIA
Gene Name
FVIII
Mutation
c.98G>A; c.1412C>G; c.1643G>A; c.1643G>A
Orivet Genetic Pet Care
GTP
GTP Name
Orivet Genetic Pet Care
Breed
OMIA
GTP Disease Name
Factor VIII Deficiency or Hemophilia A; mutation originally found in Old English Sheepdog
GTP Disease Synonym
Factor VIII Deficiency
Gene Name
FVIII
Mutation
c.98G>A
Nature of test
mutation test
FCI Number
166
GTP Breed
German shepherd dog/ Double coat
VetGen LLC
GTP
GTP Name
VetGen LLC
Breed
OMIA
Gene Name
FVIII
Mutation
c.98G>A
Wisdom Panel - Kinship
GTP
GTP Name
Wisdom Panel - Kinship
Breed
OMIA
GTP Disease Name
Factor VIII Deficiency or Hemophilia A; mutation originally found in Old English Sheepdog
GTP Disease Synonym
Factor VIII Deficiency
Gene Name
FVIII
Mutation
c.98G>A
Nature of test
mutation test
FCI Number
166
GTP Breed
German shepherd dog/ Double coat
The Kennel Club
GTP
GTP Name
The Kennel Club
Breed
OMIA
GTP Disease Name
Factor VIII Deficiency or Hemophilia A; mutation originally found in Old English Sheepdog
Gene Name
FVIII
Mutation
p.Cys548Tyr
This test is outsourced to:
Weatherby's
CMSCH
GTP
GTP Name
CMSCH
Breed
OMIA
Gene Name
FVIII
Mutation
c.98G>A; c.1412C>G; c.1643G>A; c.1643G>A
Paw Print Genetics
GTP
GTP Name
Paw Print Genetics
Breed
OMIA
GTP Disease Name
Factor VIII Deficiency or Hemophilia A; mutation originally found in Old English Sheepdog
GTP Disease Synonym
Factor VIII Deficiency
Gene Name
FVIII
Mutation
c.1643G>A; p.Cys548Tyr
Nature of test
mutation test
FCI Number
166
GTP Breed
German shepherd dog/ Double coat
Progènes-ADN
GTP
GTP Name
Progenes ADN
Breed
OMIA
Gene Name
FVIII
Mutation
c.98G>A; c.1412C>G; c.1643G>A; c.1643G>A
Veterinary Genetics Laboratory
GTP
GTP Name
Veterinary Genetics Laboratory
Breed
OMIA
GTP Disease Name
Factor VIII Deficiency or Hemophilia A; mutation originally found in Old English Sheepdog
Gene Name
FVIII
Mutation
c.98G>A
Nature of test
mutation test
PharmaDNA
GTP
GTP Name
PharmaDNA
Breed
OMIA
Gene Name
FVIII
Mutation
c.98G>A; c.1412C>G; c.1643G>A; c.1643G>A
INNO
GTP
GTP Name
INNO
Breed
OMIA
Gene Name
FVIII
Mutation
c.98G>A; c.1412C>G; c.1643G>A; c.1643G>A
Laboklin Gmbh & Co. KG
GTP
GTP Name
Laboklin Gmbh & Co. KG
Breed
OMIA
GTP Disease Name
Factor VIII Deficiency or Hemophilia A; mutation originally found in Old English Sheepdog
Gene Name
FVIII
Mutation
c.1412C>G
Nature of test
mutation test
FCI Number
166
DNA My Dog
GTP
GTP Name
DNA My Dog
Breed
OMIA
GTP Disease Name
Factor VIII Deficiency or Hemophilia A; mutation originally found in Old English Sheepdog
GTP Disease Synonym
Factor VIII Deficiency
Gene Name
FVIII
Mutation
c.98G>A
Nature of test
mutation test
This test is outsourced to:
Orivet
FCI Number
166
GTP Breed
German shepherd dog/ Double coat
Agrotis S.r.l.
GTP
GTP Name
Agrotis S.r.l.
Breed
OMIA
Gene Name
FVIII
Mutation
c.98G>A; c.1412C>G; c.1643G>A; c.1643G>A
AnimaLabs
GTP
GTP Name
AnimaLabs
Breed
OMIA
Weatherbys Scientific
GTP
GTP Name
Weatherbys Scientific
Breed
OMIA
GTP Disease Name
Factor VIII Deficiency or Hemophilia A; mutation originally found in Old English Sheepdog
Gene Name
FVIII
Mutation
c.1643G>A; p.Cys548Tyr
BioBank AS
GTP
GTP Name
BioBank AS
Breed
OMIA
Gene Name
FVIII
Mutation
c.98G>A; c.1412C>G; c.1643G>A; c.1643G>A
-
HGTD Quick Search
-
The portal for Genetic Testing Providers (labs); genetic tests, and tests by breed: as well as information on quality indicators and genetic counseling resources.
GOAL: Robust genetic testing supporting health improvements & a sustainable future for healthy dogs. -
HGTD Database Resources
How to use the HGTD
Using HGTD - YouTube Videos
HGTD Quality Indicators
Acronyms - Mode of Inheritance♦ 2020-New What is a Relevance Rating?
FAQs
Answers to frequently asked questions about the HGTD
Accreditation Basics
This brief overview may help you identify what types of accreditation are important to you, when choosing your genetic test provider.
Accreditation and Industry Standards
List of organizations throughout the world that are involved in matters of accreditation and establishing industry standards.
Choosing a Genetic Test Provider
Choosing a genetic test provider can be daunting. This short article helps you to consider what is important to you, and your dogs, in finding the right test provider for you. -
The HGTD's genetic counselling resources index provides access to basic introductory articles on genetics, articles on application of genetics in breed health management, and advanced work in technical genetics research. Breed-specific information is also available in our Pedigreed Dogs Database.
