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Improper Coat/Furnishings
Breed: ALL
Generic Phene Data
Breeds
Relevance Rating: There is some evidence or research available in this breed
Relevance Rating: The test is unknown, there is no evidence (i.e. research) available, or it has not been evaluated yet. These tests may or may not be meaningful for these breeds
General
Disease Name
Improper Coat/Furnishings
OMIA
1498
Gene Name
RSPO2
Mutation
167 bp 3' UTR insertion
Test Type
Other Genetic Traits
Details
The IC Locus determines for some breeds the variation in the dog's coat that makes its texture and appearance look different from the breed standard - i.e. change in hair type from wired to straight. It can also influence the presense or absense of "furnishings" (mustache and eyebrows). For some breeds and crosses, having the Improper Coat (IC) variation appears to be associated with dogs prone to shedding. Inherited phenotypes include: furnishings + proper coat, furnishings + improper coat, no furnishings + improper coat. The overall coat type is dependent on the combination of this dog's genotypes at the L, Cu, and IC loci.
Details 2
The IC Locus determines for some breeds the variation in the dog's coat that makes its texture and appearance look different from the breed standard - i.e. change in hair type from wired to straight. It can also influence the presense or absense of "furnishings" (mustache and eyebrows). For some breeds and crosses, having the Improper Coat (IC) variation appears to be associated with dogs prone to shedding. Inherited phenotypes include: furnishings + proper coat, furnishings + improper coat, no furnishings + improper coat. The overall coat type is dependent on the combination of this dog's genotypes at the L, Cu, and IC loci.
Published
Parker, HG., Chase, K., Cadieu, E., Lark, KG., Ostrander, EA. : An insertion in the RSPO2 gene correlates with improper coat in the Portuguese water dog. J Hered 101:612-7, 2010. Pubmed reference: 20562213. DOI: 10.1093/jhered/esq068.
Published 2
Parker, H.G., Harris, A., Dreger, D.L., Davis, B.W., Ostrander, E.A. : The bald and the beautiful: hairlessness in domestic dog breeds. Philos Trans R Soc Lond B Biol Sci 372:, 2017. Pubmed reference: 27994129. DOI: 10.1098/rstb.2015.0488.
Body/System/Process
Coat Colour/Pattern/Type
OMIA Url
Inheritance
A
Breed Specific Info
Researched Breeds
Portugese Water Dog
HSP Test-Specific Data
Zoolyx
GTP
GTP Name
Zoolyx
Breed
OMIA
Gene Name
RSPO2
Mutation
167 bp insertion in 3'UTR region
VHL Genetics
GTP
GTP Name
VHL Genetics
Breed
OMIA
Gene Name
RSPO2
Mutation
167 bp insertion in 3'UTR region
Veterinary Genetics Laboratory
GTP
GTP Name
Veterinary Genetics Laboratory
Breed
OMIA
GTP Disease Name
Improper coat
Gene Name
RSPO2
Mutation
167 bp insertion in 3'UTR region
Nature of test
mutation test
GTP- or Breed-Specific Publications
Cadieu E, Neff MW, Quignon P, Walsh K, Chase K, Parker HG, Vonholdt BM, Rhue A, Boyko A, Byers A, Wong A, Mosher DS, Elkahloun AG, Spady TC, Andr?? C, Lark KG, Cargill M, Bustamante CD, Wayne RK, Ostrander EA. Coat variation in the domestic dog is governed
FCI Number
-20
GTP Breed
ALL
Progènes-ADN
GTP
GTP Name
Progenes ADN
Breed
OMIA
Gene Name
RSPO2
Mutation
167 bp insertion in 3'UTR region
PharmaDNA
GTP
GTP Name
PharmaDNA
Breed
OMIA
Gene Name
RSPO2
Mutation
167 bp insertion in 3'UTR region
Laboratorios Labocor S.L.
GTP
GTP Name
Laboratorios Labocor S.L.
Breed
OMIA
Gene Name
RSPO2
Mutation
167 bp insertion in 3'UTR region
Laboklin Gmbh & Co. KG
GTP
GTP Name
Laboklin Gmbh & Co. KG
Breed
OMIA
GTP Disease Name
Improper coat
Gene Name
RSPO2
Mutation
167 bp insertion in 3'UTR region
Nature of test
mutation test
FCI Number
-20
INNO
GTP
GTP Name
INNO
Breed
OMIA
Gene Name
RSPO2
Mutation
167 bp insertion in 3'UTR region
GenSol Diagnostics
GTP
GTP Name
GenSol Diagnostics
Breed
OMIA
GTP Disease Name
Improper coat
Gene Name
RSPO2
Mutation
167 bp insertion in 3'UTR region
EVG Diagnostics
GTP
GTP Name
EVG Molecular Diagnostics
Breed
OMIA
Gene Name
RSPO2
Mutation
167 bp insertion in 3'UTR region
CMSCH
GTP
GTP Name
CMSCH
Breed
OMIA
Gene Name
RSPO2
Mutation
167 bp insertion in 3'UTR region
Certagen GmbH
GTP
GTP Name
Certagen GmbH
Breed
OMIA
Gene Name
RSPO2
Mutation
167 bp insertion in 3'UTR region
Generatio GmbH Center for Animal Genetics
GTP
GTP Name
Generatio GmbH Center for Animal Genetics
Breed
OMIA
Gene Name
RSPO2
Mutation
167 bp insertion in 3'UTR region
BioBank AS
GTP
GTP Name
BioBank AS
Breed
OMIA
Gene Name
RSPO2
Mutation
167 bp insertion in 3'UTR region
Antagene
GTP
GTP Name
Antagene
Breed
OMIA
GTP Disease Name
Improper coat
Gene Name
RSPO2
Mutation
167 bp insertion in 3'UTR region
Nature of test
mutation test
FCI Number
-20
GTP Breed
ALL
Agrotis S.r.l.
GTP
GTP Name
Agrotis S.r.l.
Breed
OMIA
Gene Name
RSPO2
Mutation
167 bp insertion in 3'UTR region
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